Preparation, characterization, and cellular uptake of resveratrol-loaded trimethyl chitosan nanoparticles
DC Field | Value | Language |
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dc.contributor.author | Min, Jeong Bin | - |
dc.contributor.author | Kim, Eun Suh | - |
dc.contributor.author | Lee, Ji-Soo | - |
dc.contributor.author | Lee, Hyeon Gyu | - |
dc.date.accessioned | 2022-07-12T00:49:40Z | - |
dc.date.available | 2022-07-12T00:49:40Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150257 | - |
dc.description.abstract | The aim of the study was to encapsulate resveratrol (RV) in trimethyl chitosan (TMC) nanoparticles cross-linked with tripolyphosphate (TPP) and/or alginate to achieve controlled release and improved cellular uptake. TMC (degree of quaternization of 78%) was prepared by reacting purified chitosan with iodomethane. Three types of RV-loaded TMC nanoparticles were prepared: TMC–TPP (TP-NPs), TMC–alginate (TA-NPs), and TMC–alginate–TPP (TAP-NPs). TA-NPs and TAP-NPs showed lower particle size and encapsulation efficiency (EE), better distribution, and more sustained release than TP-NPs due to the high molecular weight and viscous property of alginate. Caco-2 cellular uptake of RV was improved by TMC nanoencapsulation, and TP-NPs showed the highest uptake due to its significantly higher EE. Compared with TAP-NPs, TA-NPs with higher positive surface charge showed higher cellular uptake. Moreover, Caco-2 cell growth-inhibiting activity of RV was significantly increased by TMC nanoencapsulation and TP-NPs showed the significantly highest activity with a good agreement with the permeability results. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.title | Preparation, characterization, and cellular uptake of resveratrol-loaded trimethyl chitosan nanoparticles | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyeon Gyu | - |
dc.identifier.doi | 10.1007/s10068-017-0272-2 | - |
dc.identifier.scopusid | 2-s2.0-85045023012 | - |
dc.identifier.wosid | 000429401800016 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.27, no.2, pp.441 - 450 | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 27 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 441 | - |
dc.citation.endPage | 450 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002339944 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | ORAL INSULIN DELIVERY | - |
dc.subject.keywordPlus | L-ASCORBIC-ACID | - |
dc.subject.keywordPlus | PHYSICOCHEMICAL PROPERTIES | - |
dc.subject.keywordPlus | COMPLEX COACERVATION | - |
dc.subject.keywordPlus | PROTEIN DELIVERY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | ENCAPSULATION | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | CHLORIDE | - |
dc.subject.keywordAuthor | Trimethyl chitosan | - |
dc.subject.keywordAuthor | Nanoencapsulation | - |
dc.subject.keywordAuthor | Controlled release | - |
dc.subject.keywordAuthor | Cellular uptake | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/piq.21273 | - |
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