The antidepressant action of 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid is mediated by phosphorylation of histone deacetylase 5
DC Field | Value | Language |
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dc.contributor.author | Park, Min Hyeop | - |
dc.contributor.author | Choi, Miyeon | - |
dc.contributor.author | Kim, Yong-Seok | - |
dc.contributor.author | Son, Hyeon | - |
dc.date.accessioned | 2022-07-12T07:38:44Z | - |
dc.date.available | 2022-07-12T07:38:44Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150428 | - |
dc.description.abstract | 3-(2-Carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP), a competitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant-like effects in animal models of depression. However, the molecular mechanisms underlying these behavioral actions remain unknown. Here, we demonstrate that CPP rapidly stimulates histone deacetylase (HDAC) 5 phosphorylation and nuclear export in rat hippocampal neurons. These effects are accompanied by calcium/calmodulin kinase II (CaMKII) and protein kinase D (PKD) phosphorylation. Behavioral experiments revealed that viral-mediated hippocampal knockdown of HDAC5 blocked the antidepressant effects of CPP in stressed animals. Taken together, our results imply that CPP acts via HDAC5 and suggest that HDAC5 is a common regulator contributing to the antidepressant actions of NMDA receptor antagonists such as CPP. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | The antidepressant action of 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid is mediated by phosphorylation of histone deacetylase 5 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Seok | - |
dc.contributor.affiliatedAuthor | Son, Hyeon | - |
dc.identifier.doi | 10.4196/kjpp.2018.22.2.155 | - |
dc.identifier.scopusid | 2-s2.0-85043364765 | - |
dc.identifier.wosid | 000426608800005 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.22, no.2, pp.155 - 162 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 22 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 155 | - |
dc.citation.endPage | 162 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002323918 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | MAJOR DEPRESSIVE DISORDER | - |
dc.subject.keywordPlus | NMDA RECEPTOR BLOCKADE | - |
dc.subject.keywordPlus | HIPPOCAMPAL | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | KETAMINE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | Hippocampus | - |
dc.subject.keywordAuthor | Histone deacetylase 5 | - |
dc.subject.keywordAuthor | NMDA receptor antagonist | - |
dc.subject.keywordAuthor | Phosphorylation | - |
dc.identifier.url | https://synapse.koreamed.org/articles/1026234 | - |
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