Prognostic indicators of outcomes in patients with lung metastases from differentiated thyroid carcinoma during long-term follow-up
DC Field | Value | Language |
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dc.contributor.author | Sohn, Seo Young | - |
dc.contributor.author | Kim, Hye In | - |
dc.contributor.author | Kim, Young Nam | - |
dc.contributor.author | Kim, Tae Hyuk | - |
dc.contributor.author | Kim, Wook | - |
dc.contributor.author | Chung, Jae Hoon | - |
dc.date.accessioned | 2022-07-12T12:44:54Z | - |
dc.date.available | 2022-07-12T12:44:54Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150523 | - |
dc.description.abstract | Background: Distant metastases, although uncommon, represent maximum disease-related mortality in differentiated thyroid carcinoma (DTC). Lungs are the most frequent sites of metastases. We aimed to evaluate long-term outcomes and identify prognostic factors in metastatic DTC limited to the lungs. Methods: This retrospective study included 89 patients with DTC and metastases limited to the lungs, who were treated between 1996 and 2012 at Samsung Medical Center. Progression-free survival (PFS) and cancer-specific survival (CSS) rates were evaluated according to clinicopathologic factors. Cox regression analysis was used to identify independent factors associated with structural progressive disease (PD) and cancer-specific death. Results: With a median follow-up of 84 months, the 5- and 10-year CSS rates were 78% and 73%, respectively. Older age at diagnosis (˃= 55 years), radioactive iodine (RAI) nonavidity, preoperative or late diagnosis of metastasis and macro-nodular metastasis (˃= 1 cm) were predictive of decreased PFS and CSS. Multivariate analysis identified older age (P = .002), RAI nonavidity (P = .045) and preoperative (P = .030) or late diagnosis (P = .26) as independent predictors of structural PD. RAI avidity was also independent predictor of cancer-specific death (P = .025). Conclusion: Patients with DTC and metastatic disease limited to the lungs had favourable long-term outcomes. Age, RAI avidity and timing of metastasis were found to be major factors for predicting prognosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Prognostic indicators of outcomes in patients with lung metastases from differentiated thyroid carcinoma during long-term follow-up | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sohn, Seo Young | - |
dc.identifier.doi | 10.1111/cen.13489 | - |
dc.identifier.scopusid | 2-s2.0-85040741949 | - |
dc.identifier.wosid | 000429404400018 | - |
dc.identifier.bibliographicCitation | CLINICAL ENDOCRINOLOGY, v.88, no.2, pp.318 - 326 | - |
dc.relation.isPartOf | CLINICAL ENDOCRINOLOGY | - |
dc.citation.title | CLINICAL ENDOCRINOLOGY | - |
dc.citation.volume | 88 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 318 | - |
dc.citation.endPage | 326 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | DISTANT METASTASES | - |
dc.subject.keywordPlus | PULMONARY METASTASES | - |
dc.subject.keywordPlus | RADIOIODINE THERAPY | - |
dc.subject.keywordPlus | RADIOACTIVE IODINE | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PAPILLARY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordAuthor | differentiated thyroid carcinoma | - |
dc.subject.keywordAuthor | lung metastasis | - |
dc.subject.keywordAuthor | radioiodine | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/cen.13489 | - |
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