Alcohol intake and risk of systemic lupus erythematosus: a Mendelian randomization study
DC Field | Value | Language |
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dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-08-02T12:27:05Z | - |
dc.date.available | 2021-08-02T12:27:05Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/15053 | - |
dc.description.abstract | Objectives: This study aimed to examine whether alcohol intake is causally associated with systemic lupus erythematosus (SLE). Methods: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and an SLE GWAS consisting of 1311 SLE and 1783 control subjects of European descent as the outcome. Results: We selected 20 single nucleotide polymorphisms (SNPs) associated with alcohol intake frequency at genome-wide significance as instrumental variables to improve inference. The IVW method found no evidence to support a causal association between alcohol intake and SLE (beta = –0.413, SE = 0.513, p = 0.421). The MR-Egger regression revealed that directional pleiotropy was unlikely to bias the result (intercept = 0.031, p = 0.582). The MR-Egger analysis found no causal association between alcohol intake and SLE (beta = –1.494, SE = 1.996, p = 0.464). Likewise, the weighted median approach also did not provide evidence of a causal association between alcohol intake and SLE (beta = –0.538, SE = 0.574, p = 0.349). The MR estimates determined using the IVW, weighted median, and MR-Egger regression methods were consistent and results from a “leave-one-out” analysis demonstrated that no single SNP was driving the IVW point estimate. Conclusions: The results of MR analysis do not support a causal inverse association between alcohol intake and SLE occurrence. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.title | Alcohol intake and risk of systemic lupus erythematosus: a Mendelian randomization study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1177/0961203318817832 | - |
dc.identifier.scopusid | 2-s2.0-85060177695 | - |
dc.identifier.wosid | 000457011300004 | - |
dc.identifier.bibliographicCitation | LUPUS, v.28, no.2, pp.174 - 180 | - |
dc.relation.isPartOf | LUPUS | - |
dc.citation.title | LUPUS | - |
dc.citation.volume | 28 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 174 | - |
dc.citation.endPage | 180 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | INSTRUMENTAL VARIABLES | - |
dc.subject.keywordPlus | GENETIC-VARIANTS | - |
dc.subject.keywordPlus | CONSUMPTION | - |
dc.subject.keywordAuthor | Alcohol intake | - |
dc.subject.keywordAuthor | systemic lupus erythematosus | - |
dc.subject.keywordAuthor | Mendelian randomization | - |
dc.identifier.url | https://journals.sagepub.com/doi/10.1177/0961203318817832 | - |
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