Longitudinal cortical thinning and cognitive decline in patients with early- versus late-stage subcortical vascular mild cognitive impairment
DC Field | Value | Language |
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dc.contributor.author | Lee, J. | - |
dc.contributor.author | Seo, S. W. | - |
dc.contributor.author | Yang, J. -J. | - |
dc.contributor.author | Jang, Y. K. | - |
dc.contributor.author | Lee, J. S. | - |
dc.contributor.author | Kim, Y. J. | - |
dc.contributor.author | Chin, J. | - |
dc.contributor.author | Lee, Jong Min | - |
dc.contributor.author | Kim, S. T. | - |
dc.contributor.author | Lee, K. -H. | - |
dc.contributor.author | Lee, J. H. | - |
dc.contributor.author | Kim, J. S. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Yoo, H. | - |
dc.contributor.author | Lee, A. Y. | - |
dc.contributor.author | Na, D. L. | - |
dc.contributor.author | Kim, H. J. | - |
dc.date.accessioned | 2022-07-12T13:02:37Z | - |
dc.date.available | 2022-07-12T13:02:37Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 1351-5101 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150615 | - |
dc.description.abstract | Background and purposeBiomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients. MethodsSeventy-two svMCI patients were divided into early stage (ES-svMCI, n = 39) and late stage (LS-svMCI, n = 33) according to their Clinical Dementia Rating Sum of Boxes score. Patients were annually followed up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and underwent a second [C-11] Pittsburgh compound B (PiB) positron emission tomography scan within a mean interval of 32.4 months. ResultsThere was no difference in the rate of increase in PiB uptake or lacune number between the ES-svMCI and LS-svMCI. However, LS-svMCI showed more rapid cortical thinning and cognitive decline than did the ES-svMCI. ConclusionsWe suggest that, whilst the rate of change in pathological burden did not differ between ES-svMCI and LS-svMCI, cortical thinning and cognitive decline progressed more rapidly in the LS-svMCI. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Longitudinal cortical thinning and cognitive decline in patients with early- versus late-stage subcortical vascular mild cognitive impairment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jong Min | - |
dc.identifier.doi | 10.1111/ene.13500 | - |
dc.identifier.scopusid | 2-s2.0-85040811670 | - |
dc.identifier.wosid | 000422971000028 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NEUROLOGY, v.25, no.2, pp.326 - 333 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NEUROLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF NEUROLOGY | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 326 | - |
dc.citation.endPage | 333 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | SMALL VESSEL DISEASE | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | THICKNESS | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | PIPELINE | - |
dc.subject.keywordAuthor | cognition | - |
dc.subject.keywordAuthor | cortical thickness | - |
dc.subject.keywordAuthor | early stage | - |
dc.subject.keywordAuthor | late stage | - |
dc.subject.keywordAuthor | subcortical vascular mild cognitive impairment | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/ene.13500 | - |
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