Irisin is a biomarker for metabolic syndrome in prepubertal children
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, Young Suk | - |
dc.contributor.author | Kang, Min Jae | - |
dc.contributor.author | Yang, Seung | - |
dc.contributor.author | Hwang, Il Tae | - |
dc.date.accessioned | 2022-07-12T17:13:02Z | - |
dc.date.available | 2022-07-12T17:13:02Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 0918-8959 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150681 | - |
dc.description.abstract | The aim of the present study was to evaluate the association of irisin with obesity and metabolic syndrome (MetS) in Korean prepubertal children. A total of 96 children and adolescents aged 6 to 10 years (56 males) were included in this study. Subjects were divided into 3 groups: normal weight (n = 54), overweight (n = 16), and obese (n = 26). In the subgroup analyses, overweight/obese children were further divided based on their MetS status (with MetS vs. without MetS). Children with obesity tended to exhibit a lower mean irisin concentration compared to those with normal weight (p = 0.028). Using Pearson's correlation coefficient to compare all the children in the study, there was a significant inverse correlation between irisin and body mass index (BMI) standard deviation scores (SDS) (r = -0.210, p = 0.041), waist circumference SDS (r = -0.203, p = 0.049), and glucose (r = -0.296, p = 0.004). In the subgroup analyses of overweight/obese children, irisin exhibited a significant inverse correlation with glucose (r = -0.507, p = 0.001) and triglycerides (r = -0.331, p = 0.033). Children with MetS exhibited lower irisin concentrations than those without MetS (14.70 ng/mL vs. 22.02 ng/mL, p = 0.001), and these associations were significant after adjusting for age, gender. and BMI SDS (14.51 ng/mL vs. 22.06 ng/mL, p = 0.002). The irisin level of 15.43 ng/mL was determined to be a possible cutoff to distinguish children with metabolic syndrome from overweight/obese children, with a sensitivity of 75% and a specificity of 94% (p < 0.001). Our results suggest that decreased irisin levels may be associated with MetS in prepubertal children and that irisin might be a biomarker for MetS in prepubertal children. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | JAPAN ENDOCRINE SOC | - |
dc.title | Irisin is a biomarker for metabolic syndrome in prepubertal children | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yang, Seung | - |
dc.identifier.doi | 10.1507/endocrj.EJ17-0260 | - |
dc.identifier.scopusid | 2-s2.0-85041291050 | - |
dc.identifier.wosid | 000454313200003 | - |
dc.identifier.bibliographicCitation | ENDOCRINE JOURNAL, v.65, no.1, pp.23 - 31 | - |
dc.relation.isPartOf | ENDOCRINE JOURNAL | - |
dc.citation.title | ENDOCRINE JOURNAL | - |
dc.citation.volume | 65 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 23 | - |
dc.citation.endPage | 31 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | CIRCULATING IRISIN | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | ADOLESCENTS | - |
dc.subject.keywordPlus | CHILDHOOD | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | OBESE | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordAuthor | Irisin | - |
dc.subject.keywordAuthor | Overweight | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Metabolic syndrome | - |
dc.subject.keywordAuthor | Children | - |
dc.identifier.url | https://www.jstage.jst.go.jp/article/endocrj/65/1/65_EJ17-0260/_article | - |
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