Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
DC Field | Value | Language |
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dc.contributor.author | Lee, Hong-Gyun | - |
dc.contributor.author | Lee, Jae-Ung | - |
dc.contributor.author | Kim, Do-Hyun | - |
dc.contributor.author | Lim, Sangho | - |
dc.contributor.author | Kang, Insoo | - |
dc.contributor.author | Choi, Je-Min | - |
dc.date.accessioned | 2021-08-02T12:27:29Z | - |
dc.date.available | 2021-08-02T12:27:29Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/15075 | - |
dc.description.abstract | T cells generate antigen-specific immune responses to their cognate antigen as a hallmark of adaptive immunity. Despite the importance of antigen-specific T cells, here we show that antigen non-related, bystander memory-like CD4(+) T cells also significantly contribute to autoimmune pathogenesis. Transcriptome analysis demonstrates that interleukin (IL)-1 beta- and IL-23-prime T cells that express pathogenic T(.)17 signature genes such as ROR gamma t, CCR6, and granulocyte macrophage colony-stimulating factor (GM-CSF). Importantly, when co-transferred with myelin-specific 2D2 TCR-transgenic naive T cells, unrelated OT-II TCR-transgenic memory-like T(H)17 cells infiltrate the spinal cord and produce IL-17A, interferon (IFN)-gamma, and GM-CSF, increasing the susceptibility of the recipients to experimental autoimmune encephalomyelitis in an IL-1 receptor-dependent manner. In humans, IL-1R1(high) memory CD4(+) T cells are major producers of IL-17A and IFN-gamma in response to IL-1 beta and IL-23. Collectively, our findings reveal the innate-like pathogenic function of antigen non-related memory CD4(+) T cells, which contributes to the development of autoimmune diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Je-Min | - |
dc.identifier.doi | 10.1038/s41467-019-08482-w | - |
dc.identifier.scopusid | 2-s2.0-85061491145 | - |
dc.identifier.wosid | 000458398900003 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.10, no.1, pp.1 - 14 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 14 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | INNATE LYMPHOID-CELLS | - |
dc.subject.keywordPlus | ROR-GAMMA-T | - |
dc.subject.keywordPlus | CYTOKINE GM-CSF | - |
dc.subject.keywordPlus | DIFFERENTIATION PROGRAM | - |
dc.subject.keywordPlus | MULTIPLE-SCLEROSIS | - |
dc.subject.keywordPlus | HELPER-CELLS | - |
dc.subject.keywordPlus | T(H)17 CELLS | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | NKT CELLS | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.identifier.url | https://www.nature.com/articles/s41467-019-08482-w | - |
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