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Cited 2 time in webofscience Cited 2 time in scopus
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Low dose radiation regulates BRAF-induced thyroid cellular dysfunction and transformation

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dc.contributor.authorKaushik, Neha-
dc.contributor.authorKim, Min-Jung-
dc.contributor.authorKaushik, Nagendra Kumar-
dc.contributor.authorMyung, Jae Kyung-
dc.contributor.authorChoi, Mi-Young-
dc.contributor.authorKang, Jae-Hyeok-
dc.contributor.authorCha, Hyuk-Jin-
dc.contributor.authorKim, Cha-Soon-
dc.contributor.authorNam, Seon-Young-
dc.contributor.authorLee, Su-Jae-
dc.date.accessioned2021-08-02T12:27:29Z-
dc.date.available2021-08-02T12:27:29Z-
dc.date.created2021-05-12-
dc.date.issued2019-02-
dc.identifier.issn1478-811X-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/15076-
dc.description.abstractBackground: The existence of differentiated thyroid cells is critical to respond radioactive iodide treatment strategy in thyroid cancer, and loss of the differentiated phenotype is a trademark of iodide-refractive thyroid disease. While high-dose therapy has been beneficial to several cancer patients, many studies have indicated this clinical benefit was limited to patients having BRAF mutation. BRAF-targeted paired box gene-8 (PAX8), a thyroid-specific transcription factor, generally dysregulated in BRAF-mutated thyroid cancer. Methods: In this study, thyroid iodine-metabolizing gene levels were detected in BRAF-transformed thyroid cells after low and high dose of ionizing radiation. Also, an mRNA-targeted approach was used to figure out the underlying mechanism of low (0.01Gyx10 or 0.1Gy) and high (2Gy) radiation function on thyroid cancer cells after BRAF(V600E) mutation. Results: Low dose radiation (LDR)-induced PAX8 upregulation restores not only BRAF-suppressive sodium/iodide symporter (NIS) expression, one of the major protein necessary for iodine uptake in healthy thyroid, on plasma membrane but also regulate other thyroid metabolizing genes levels. Importantly, LDR-induced PAX8 results in decreased cellular transformation in BRAF-mutated thyroid cells. Conclusion: The present findings provide evidence that LDR-induced PAX8 acts as an important regulator for suppression of thyroid carcinogenesis through novel STAT3/miR-330-5p pathway in thyroid cancers.-
dc.language영어-
dc.language.isoen-
dc.publisherBMC-
dc.titleLow dose radiation regulates BRAF-induced thyroid cellular dysfunction and transformation-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Su-Jae-
dc.identifier.doi10.1186/s12964-019-0322-x-
dc.identifier.scopusid2-s2.0-85061486615-
dc.identifier.wosid000458626700001-
dc.identifier.bibliographicCitationCELL COMMUNICATION AND SIGNALING, v.17, no.1, pp.1 - 13-
dc.relation.isPartOfCELL COMMUNICATION AND SIGNALING-
dc.citation.titleCELL COMMUNICATION AND SIGNALING-
dc.citation.volume17-
dc.citation.number1-
dc.citation.startPage1-
dc.citation.endPage13-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusPAPILLARY-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusCARCINOMA-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusTARGET-
dc.subject.keywordPlusRAS-
dc.subject.keywordPlusCELLS-
dc.subject.keywordAuthorLow dose radiation-
dc.subject.keywordAuthorLDR-
dc.subject.keywordAuthorThyroid cancer-
dc.subject.keywordAuthorPaired-box domain 8-
dc.subject.keywordAuthorPAX8-
dc.subject.keywordAuthormiR-330-5p-
dc.subject.keywordAuthorThyroglobulin-
dc.subject.keywordAuthorTG-
dc.identifier.urlhttps://biosignaling.biomedcentral.com/articles/10.1186/s12964-019-0322-x-
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서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles

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