Low dose radiation regulates BRAF-induced thyroid cellular dysfunction and transformation
DC Field | Value | Language |
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dc.contributor.author | Kaushik, Neha | - |
dc.contributor.author | Kim, Min-Jung | - |
dc.contributor.author | Kaushik, Nagendra Kumar | - |
dc.contributor.author | Myung, Jae Kyung | - |
dc.contributor.author | Choi, Mi-Young | - |
dc.contributor.author | Kang, Jae-Hyeok | - |
dc.contributor.author | Cha, Hyuk-Jin | - |
dc.contributor.author | Kim, Cha-Soon | - |
dc.contributor.author | Nam, Seon-Young | - |
dc.contributor.author | Lee, Su-Jae | - |
dc.date.accessioned | 2021-08-02T12:27:29Z | - |
dc.date.available | 2021-08-02T12:27:29Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 1478-811X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/15076 | - |
dc.description.abstract | Background: The existence of differentiated thyroid cells is critical to respond radioactive iodide treatment strategy in thyroid cancer, and loss of the differentiated phenotype is a trademark of iodide-refractive thyroid disease. While high-dose therapy has been beneficial to several cancer patients, many studies have indicated this clinical benefit was limited to patients having BRAF mutation. BRAF-targeted paired box gene-8 (PAX8), a thyroid-specific transcription factor, generally dysregulated in BRAF-mutated thyroid cancer. Methods: In this study, thyroid iodine-metabolizing gene levels were detected in BRAF-transformed thyroid cells after low and high dose of ionizing radiation. Also, an mRNA-targeted approach was used to figure out the underlying mechanism of low (0.01Gyx10 or 0.1Gy) and high (2Gy) radiation function on thyroid cancer cells after BRAF(V600E) mutation. Results: Low dose radiation (LDR)-induced PAX8 upregulation restores not only BRAF-suppressive sodium/iodide symporter (NIS) expression, one of the major protein necessary for iodine uptake in healthy thyroid, on plasma membrane but also regulate other thyroid metabolizing genes levels. Importantly, LDR-induced PAX8 results in decreased cellular transformation in BRAF-mutated thyroid cells. Conclusion: The present findings provide evidence that LDR-induced PAX8 acts as an important regulator for suppression of thyroid carcinogenesis through novel STAT3/miR-330-5p pathway in thyroid cancers. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.title | Low dose radiation regulates BRAF-induced thyroid cellular dysfunction and transformation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Su-Jae | - |
dc.identifier.doi | 10.1186/s12964-019-0322-x | - |
dc.identifier.scopusid | 2-s2.0-85061486615 | - |
dc.identifier.wosid | 000458626700001 | - |
dc.identifier.bibliographicCitation | CELL COMMUNICATION AND SIGNALING, v.17, no.1, pp.1 - 13 | - |
dc.relation.isPartOf | CELL COMMUNICATION AND SIGNALING | - |
dc.citation.title | CELL COMMUNICATION AND SIGNALING | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | PAPILLARY | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | RAS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Low dose radiation | - |
dc.subject.keywordAuthor | LDR | - |
dc.subject.keywordAuthor | Thyroid cancer | - |
dc.subject.keywordAuthor | Paired-box domain 8 | - |
dc.subject.keywordAuthor | PAX8 | - |
dc.subject.keywordAuthor | miR-330-5p | - |
dc.subject.keywordAuthor | Thyroglobulin | - |
dc.subject.keywordAuthor | TG | - |
dc.identifier.url | https://biosignaling.biomedcentral.com/articles/10.1186/s12964-019-0322-x | - |
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