Understanding the role of glycogen synthase kinase-3 in L-DOPA-induced dyskinesia in Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | Choi, Ho jin | - |
dc.contributor.author | Koh, Seong Ho | - |
dc.date.accessioned | 2022-07-12T20:01:30Z | - |
dc.date.available | 2022-07-12T20:01:30Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1742-5255 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150896 | - |
dc.description.abstract | Introduction: Levodopa (L-DOPA) is the most commonly used drug for Parkinson's disease (PD), but its long-term use is associated with various complications, including L-DOPA-induced dyskinesia (LID). Many studies have suggested that L-DOPA neurotoxicity and LID are associated with glycogen synthase kinase-3 (GSK-3) activation. Areas covered: LID is caused by striatal dopamine (DA) denervation in PD and pulsatile L-DOPA treatment. These factors lead to dysregulated DA transmission, abnormal intracellular signaling and transcription factors in striatal neurons, and altered gene expression and plasticity at corticostriatal synapses. The mechanisms of L-DOPA toxicity involve oxidative stress, L-DOPA oxidation to quinone, mitochondrial dysfunction, and a-synuclein. GSK-3 has been suggested to play key roles in all the mechanisms associated of L-DOPA toxicity and LID in PD. Expert opinion: GSK-3 plays critical roles in L-DOPA-induced neurotoxicity, and the development of specific methods to inhibit GSK-3 function may help prevent L-DOPA neurotoxicity and LID in PD. However, balanced GSK-3 inhibition and less beta-catenin degradation is essential for preventing LID, because too much GSK-3 inhibition increases beta-catenin levels, which is related to cancers. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Understanding the role of glycogen synthase kinase-3 in L-DOPA-induced dyskinesia in Parkinson's disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Ho jin | - |
dc.contributor.affiliatedAuthor | Koh, Seong Ho | - |
dc.identifier.doi | 10.1080/17425255.2018.1417387 | - |
dc.identifier.scopusid | 2-s2.0-85039788949 | - |
dc.identifier.wosid | 000429110800008 | - |
dc.identifier.bibliographicCitation | EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, v.14, no.1, pp.83 - 90 | - |
dc.relation.isPartOf | EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | - |
dc.citation.title | EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 83 | - |
dc.citation.endPage | 90 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | LEVODOPA-INDUCED DYSKINESIA | - |
dc.subject.keywordPlus | ALPHA-SYNUCLEIN | - |
dc.subject.keywordPlus | RAT MODEL | - |
dc.subject.keywordPlus | INDUCED NEUROTOXICITY | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | DENERVATED STRIATUM | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | RECEPTOR SUBUNITS | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | glycogen synthase kinase-3 (GSK-3) | - |
dc.subject.keywordAuthor | l-3 | - |
dc.subject.keywordAuthor | 4-dihydroxyphenylalanine (L-DOPA) | - |
dc.subject.keywordAuthor | neurotoxicity | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/17425255.2018.1417387 | - |
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