Reproductive factors as risk modifiers of breast cancer in BRCA mutation carriers and high-risk non-carriers
DC Field | Value | Language |
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dc.contributor.author | Park, Bo young | - |
dc.contributor.author | Hopper, John L. | - |
dc.contributor.author | Win, Aung K. | - |
dc.contributor.author | Dowty, James G. | - |
dc.contributor.author | Sung, Ho Kyung | - |
dc.contributor.author | Ahn, Choonghyun | - |
dc.contributor.author | Kim, Sung-Won | - |
dc.contributor.author | Lee, Min Hyuk | - |
dc.contributor.author | Lee, Jihyoun | - |
dc.contributor.author | Park, Sue K. | - |
dc.date.accessioned | 2022-07-12T23:47:24Z | - |
dc.date.available | 2022-07-12T23:47:24Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151174 | - |
dc.description.abstract | This study was conducted to identify the role of reproductive factors as environmental modifiers for breast cancer (BC) risk in clinic-based, East-Asian BRCA1 and BRCA2 mutation carriers and non-carriers with high-risk criteria of BRCA mutations (family history (FH) of BC, early-onset BC (aged ≤40 years)). A total of 581 women who were BRCA carriers (222 BRCA1 and 359 BRCA2), 1,083 non-carriers with FH, and 886 non-carriers with early-onset BC were enrolled and interviewed to examine the reproductive factors, from 2007 to 2014. The hazard ratio (HR) and its 95% confidence interval (CI) in the weighted Cox regression model were used to calculate the BC risk based on the reproductive factors. Earlier menarche increased BC risk by 3.49-fold in BRCA2 mutation carriers (95%CI=2.03-6.00) and 3.30-fold in non-carriers with FH (95%CI=1.73-6.34), but was insignificantly associated with BRCA1 carriers and non-carriers for early-onset BC (P-heterogeneity=0.047). Higher parity decreased BC risk in BRCA carriers and non-carriers with FH, especially in BRCA1 carriers (HR=0.27, 95% CI=0.09-0.83 for two parity; and HR=0.23, 95%CI=0.05-1.00 for ≥3 parity), but increased the early-onset BC risk (HR=4.63, 95%CI=2.56-8.51 for >3 parity, p-heterogeneity=0.045). Oral contraceptive (OC) use and longer estrogen exposure periods (≥30 years) were associated with an increased risk of early-onset BC (HR=3.99, 95%CI=1.65-9.67; HR=7.69, 95%CI=1.96-25.01), while OC use was not associated with BC risk in other groups and longer estrogen exposure had rather decreased risk for BC risk (both p-heterogeneity<0.001). Several reproductive factors as risk modifiers could heterogeneously be associated with BC among BRCA1/2 mutation carriers, non-carriers with FH, and early-onset BC non-carriers. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Impact Journals | - |
dc.title | Reproductive factors as risk modifiers of breast cancer in BRCA mutation carriers and high-risk non-carriers | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Bo young | - |
dc.identifier.doi | 10.18632/oncotarget.22193 | - |
dc.identifier.scopusid | 2-s2.0-85034852534 | - |
dc.identifier.wosid | 000419533200092 | - |
dc.identifier.bibliographicCitation | Oncotarget, v.8, no.60, pp.102110 - 102118 | - |
dc.relation.isPartOf | Oncotarget | - |
dc.citation.title | Oncotarget | - |
dc.citation.volume | 8 | - |
dc.citation.number | 60 | - |
dc.citation.startPage | 102110 | - |
dc.citation.endPage | 102118 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.subject.keywordAuthor | BRCA1/2 mutation carriers | - |
dc.subject.keywordAuthor | breast neoplasm | - |
dc.subject.keywordAuthor | early onset breast cancer | - |
dc.subject.keywordAuthor | familial breast cancer | - |
dc.subject.keywordAuthor | reproductive factors | - |
dc.identifier.url | https://www.oncotarget.com/article/22193/text/ | - |
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