Functional repertoire of interleukin-6 in the central nervous system - a review
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Heese, Klaus | - |
dc.date.accessioned | 2022-07-12T23:50:52Z | - |
dc.date.available | 2022-07-12T23:50:52Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 0922-6028 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151226 | - |
dc.description.abstract | In an aging society with dementia imposing an increasing threat to higher brain cognitive functions, understanding the molecular and cellular events of adult neurogenesis is imperative. Interleukin-6 (IL-6), along with its agonistic acting soluble receptor sIL-6R (the combined proteins are also known as Hyper-IL-6), is a promising cytokine that can support neurogenesis under conditions of neurodegeneration when neuron replacement is needed. In contrast to the previously reported gliogenic effects of activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis, this review summarizes recent studies showing that IL-6 activation can be neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.title | Functional repertoire of interleukin-6 in the central nervous system - a review | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Heese, Klaus | - |
dc.identifier.doi | 10.3233/RNN-170772 | - |
dc.identifier.scopusid | 2-s2.0-85035127767 | - |
dc.identifier.wosid | 000416144800010 | - |
dc.identifier.bibliographicCitation | RESTORATIVE NEUROLOGY AND NEUROSCIENCE, v.35, no.6, pp.693 - 701 | - |
dc.relation.isPartOf | RESTORATIVE NEUROLOGY AND NEUROSCIENCE | - |
dc.citation.title | RESTORATIVE NEUROLOGY AND NEUROSCIENCE | - |
dc.citation.volume | 35 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 693 | - |
dc.citation.endPage | 701 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | NEURONAL DIFFERENTIATION | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | CHANNEL ACTIVITY | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | CA2+ OVERLOAD | - |
dc.subject.keywordPlus | IL-6 | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | NEUROGENESIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Brain | - |
dc.subject.keywordAuthor | IL-6 | - |
dc.subject.keywordAuthor | neural stem cell | - |
dc.subject.keywordAuthor | neurogenesis | - |
dc.subject.keywordAuthor | neuron | - |
dc.subject.keywordAuthor | signaling | - |
dc.subject.keywordAuthor | synapse | - |
dc.identifier.url | https://content.iospress.com/articles/restorative-neurology-and-neuroscience/rnn170772 | - |
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