A genetic variant in SLC28A3, rs56350726, is associated with progression to castration-resistant prostate cancer in a Korean population with metastatic prostate cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jo, Jung Ku | - |
dc.contributor.author | Oh, Jong Jin | - |
dc.contributor.author | Kim, Yong Tae | - |
dc.contributor.author | Moon, Hong Sang | - |
dc.contributor.author | Choi, Hong Yong | - |
dc.contributor.author | Park, Seunghyun | - |
dc.contributor.author | Ho, Jin-Nyoung | - |
dc.contributor.author | Yoon, Sungroh | - |
dc.contributor.author | Park, Hae Young | - |
dc.contributor.author | Byun, Seok-Soo | - |
dc.date.accessioned | 2022-07-13T04:28:54Z | - |
dc.date.available | 2022-07-13T04:28:54Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151388 | - |
dc.description.abstract | Background: Genetic variation which related with progression to castration-resistant prostate cancer (CRPC) during androgen-deprivation therapy (ADT) has not been elucidated in patients with metastatic prostate cancer (mPCa). Therefore, we assessed the association between genetic variats in mPCa and progession to CRPC. Results: Analysis of exome genotypes revealed that 42 SNPs were significantly associated with mPCa. The top five polymorphisms were statistically significantly associated with metastatic disease. In addition, one of these SNPs, rs56350726, was significantly associated with time to CRPC in Kaplan-Meier analysis (Log-rank test, p = 0.011). In multivariable Cox regression, rs56350726 was strongly associated with progression to CRPC (HR = 4.172 95% CI = 1.223-14.239, p = 0.023). Materials and Methods: We assessed genetic variation among 1000 patients with PCa with or without metastasis, using 242,221 single nucleotide polymorphisms (SNPs) on the custom HumanExome BeadChip v1.0 (Illuminam Inc.). We analyzed the time to CRPC in 110 of the 1000 patients who were treated with ADT. Genetic data were analyzed using unconditional logistic regression and odds ratios calculated as estimates of relative risk of metastasis. We identified SNPs associated with metastasis and analyzed the relationship between these SNPs and time to CRPC in mPCa. Conclusions: Based on a genetic variation, the five top SNPs were observed to associate with mPCa. And one (SLC28A3, rs56350726) of five SNP was found the association with the progression to CRPC in patients with mPCa. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | A genetic variant in SLC28A3, rs56350726, is associated with progression to castration-resistant prostate cancer in a Korean population with metastatic prostate cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jo, Jung Ku | - |
dc.contributor.affiliatedAuthor | Kim, Yong Tae | - |
dc.contributor.affiliatedAuthor | Moon, Hong Sang | - |
dc.contributor.affiliatedAuthor | Choi, Hong Yong | - |
dc.identifier.doi | 10.18632/oncotarget.18298 | - |
dc.identifier.scopusid | 2-s2.0-85033788634 | - |
dc.identifier.wosid | 000419395000044 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.8, no.57, pp.96893 - 96902 | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 8 | - |
dc.citation.number | 57 | - |
dc.citation.startPage | 96893 | - |
dc.citation.endPage | 96902 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | CONCENTRATIVE NUCLEOSIDE TRANSPORTER-3 | - |
dc.subject.keywordPlus | SINGLE NUCLEOTIDE POLYMORPHISMS | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | prostate cancer | - |
dc.subject.keywordAuthor | castration | - |
dc.subject.keywordAuthor | genetic variation | - |
dc.identifier.url | https://www.oncotarget.com/article/18298/text/ | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.