Fetuin-A as an Alternative Marker for Insulin Resistance and Cardiovascular Risk in Prepubertal Children
DC Field | Value | Language |
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dc.contributor.author | Shim, Young Suk | - |
dc.contributor.author | Kang, Min Jae | - |
dc.contributor.author | Oh, Yeon Jeong | - |
dc.contributor.author | Baek, Joon Woo | - |
dc.contributor.author | Yang, Seung | - |
dc.contributor.author | Hwang, Il Tae | - |
dc.date.accessioned | 2022-07-13T04:33:44Z | - |
dc.date.available | 2022-07-13T04:33:44Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1340-3478 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151452 | - |
dc.description.abstract | Aim: Fetuin-A plays a role in insulin resistance and cardiovascular disease. This study aims to determine the relationship between fetuin-A levels and cardiometabolic risk factors, as well as to investigate the effect of serum fetuin-A on insulin resistance indices to determine whether fetuin-A is an additional marker for insulin resistance in prepubertal children. Methods: A total of 99 prepubertal Korean children (59 males) aged from 6.0 to 10.0 years was included in this study. Subjects were divided into underweight/normal-weight and overweight/obese groups. Serum fetuin-A levels were measured using an enzyme-linked immunosorbent assay and were natural logarithm (ln)-transformed. Results: Serum fetuin-A concentrations were significantly elevated in overweight/obese children as compared with underweight/normal-weight children (P=0.029). Ln serum fetuin-A was significantly positively correlated with body mass index (BMI) standard deviation scores (SDSs) (r = 0.239, P=0.017), triglyceride levels (r=0.285, P=0.004), ln insulin (r=0.377, P<0.001), systolic blood pressure (BP) (r = 0.274, P=0.006), and diastolic BP (r = 0.304, P=0.006) and was significantly inversely correlated with high-density lipoprotein cholesterol (HDL-C) levels (r=-0.236, P=0.019). In univariate linear regression analysis, ln fetuin-A was significantly positively associated with the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.356, P<0.001) and significantly inversely associated with the quantitative insulin sensitivity check index (QUICKI) (r = 0.309, P=0.002). Following adjustment for age, gender, BMI, and lipid profiles in multivariate linear regression analysis, fetuin-A was significantly positively associated with HOMA-IR (P=0.048) and marginally inversely associated with QUICKI (P=0.054). Conclusions: Our results suggest that fetuin-A can be an alternative marker for insulin resistance and cardiovascular risk in prepubertal children. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | JAPAN ATHEROSCLEROSIS SOC | - |
dc.title | Fetuin-A as an Alternative Marker for Insulin Resistance and Cardiovascular Risk in Prepubertal Children | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yang, Seung | - |
dc.identifier.doi | 10.5551/jat.38323 | - |
dc.identifier.scopusid | 2-s2.0-85015906232 | - |
dc.identifier.wosid | 000422988700007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, v.24, no.10, pp.1031 - 1038 | - |
dc.relation.isPartOf | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | - |
dc.citation.title | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | - |
dc.citation.volume | 24 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1031 | - |
dc.citation.endPage | 1038 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | TYPE-2 DIABETES-MELLITUS | - |
dc.subject.keywordPlus | FATTY LIVER-DISEASE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | SERUM FETUIN | - |
dc.subject.keywordPlus | CHILDHOOD ADIPOSITY | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | NATIONAL-HEALTH | - |
dc.subject.keywordPlus | WEIGHT-LOSS | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordAuthor | Fetuin-A | - |
dc.subject.keywordAuthor | Insulin resistance | - |
dc.subject.keywordAuthor | Cardiovascular risk | - |
dc.subject.keywordAuthor | Children | - |
dc.subject.keywordAuthor | Obesity | - |
dc.identifier.url | https://www.jstage.jst.go.jp/article/jat/24/10/24_38323/_article | - |
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