Comparison of several dosing schedules of intravenous dexmedetomidine in elderly patients under spinal anesthesia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeom, Jong Hoon | - |
dc.contributor.author | Ahn, Dae-woong | - |
dc.contributor.author | Kim, Kyoung Hun | - |
dc.date.accessioned | 2022-07-13T04:34:58Z | - |
dc.date.available | 2022-07-13T04:34:58Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1975-5171 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151474 | - |
dc.description.abstract | Background: Many clinicians have probably used subjective, unscientific methods for dose reduction to avoid overdose in elderly patients. The aim of this study was to compare several dosing schedules of intravenous dexmedetomidine (DEX) to identify the appropriate dosing schedule within the therapeutic dose range for adequate sedation of elderly patients under spinal anesthesia. Methods: After administration of spinal anesthesia, a loading dose of DEX was injected over 10 min in three groups with the following dosages: group A, 1.0 mg/kg of actual body weight; group B, 1.0 mg/kg of ideal body weight (IBW); and group C, 0.8 mg/kg of IBW. Then, a maintenance infusion (0.5 mg/kg of each BW/h) was administered. The bispectral index score (BIS), the time required to reach BIS 80, airway obstruction score, and the occurrence of bradycardia were recorded. Results: The changes in the BIS among the groups over time were found to have statistically significant differences (P < 0.001). The times required to reach BIS 80 were 6.1 ± 5.3 min, 5.0 ± 3.6 min, and 11.0 ± 8.6 min in groups A, B, and C, respectively (P < 0.001). The airway obstruction score and the frequency of bradycardia did not have statistically significant differences among the groups. Conclusions: An initial loading dose of DEX that is 0.8 mg/kg of IBW over 10 min, followed by an infusion rate of less than 0.5 mg/kg of IBW/h may be adequate for sedation in elderly patients receiving spinal anesthesia. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한마취통증의학회 | - |
dc.title | Comparison of several dosing schedules of intravenous dexmedetomidine in elderly patients under spinal anesthesia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yeom, Jong Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Kyoung Hun | - |
dc.identifier.doi | 10.17085/apm.2017.12.4.320 | - |
dc.identifier.bibliographicCitation | Anesthesia and Pain Medicine, v.12, no.4, pp.320 - 325 | - |
dc.relation.isPartOf | Anesthesia and Pain Medicine | - |
dc.citation.title | Anesthesia and Pain Medicine | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 320 | - |
dc.citation.endPage | 325 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002278387 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Dexmedetomidine | - |
dc.subject.keywordAuthor | Ideal body weight | - |
dc.subject.keywordAuthor | Sedation | - |
dc.subject.keywordAuthor | Spinal anesthesia. | - |
dc.identifier.url | https://www.anesth-pain-med.org/journal/view.php?id=10.17085/apm.2017.12.4.320 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.