Potential of synthetic endoperoxides against Trichomonas vaginalis in vitro
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Min-Young | - |
dc.contributor.author | Ryu, Jae-Sook | - |
dc.contributor.author | Sato, Akira | - |
dc.contributor.author | Kurosaki, Yuji | - |
dc.contributor.author | Chang, Kyung-Soo | - |
dc.contributor.author | Kim, Hye-Sook | - |
dc.date.accessioned | 2022-07-13T04:35:38Z | - |
dc.date.available | 2022-07-13T04:35:38Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1383-5769 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151483 | - |
dc.description.abstract | Metronidazole is well known for medicine against Trichomonas vaginalis infection, but it has side effects though it is effective, and especially because reports of metronidazole-tolerant species are increasing, the development of new medicine is being required. Here, we noticed the killing effects of endoperoxide compounds, N-89 and N-251 as new antimalarial drug candidates, on T. vaginalis and searched the possibility of development of new medicine. We added each of metronidazole, artemisinin, and two of new endoperoxides (N-89 and N-251) to metronidazole-resistant and -sensitive species and compared its anti-trichomonal efficacy. For metronidazole, IC50 value, 50% of killing concentration for T. vaginalis, was very low for metronidazole-sensitive isolates (11.7 to 22.8 mu M), but was high for metronidazole-resistant ones (182.9 to 730.4 mu M). The IC50 values of N-89 and N-251 were 41.0 to 60.0 mu M, and 82.0 to 300.0 mu M for metronidazole-sensitive and-resistant isolates, respectively. In conclusion, we found the endoperoxides, N-89 and N-251, have anti-trichomonal effect against metronidazole-resistant T. vaginalis as well as metronidazole-sensitive ones. These results indicate that the anti-richomonal effects for our endoperoxides are equivalent or better in metronidazole-resistant T. vaginalis in comparison to metronidazole. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Potential of synthetic endoperoxides against Trichomonas vaginalis in vitro | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, Jae-Sook | - |
dc.identifier.doi | 10.1016/j.parint.2017.05.008 | - |
dc.identifier.scopusid | 2-s2.0-85021863511 | - |
dc.identifier.wosid | 000409154000019 | - |
dc.identifier.bibliographicCitation | PARASITOLOGY INTERNATIONAL, v.66, no.5, pp.619 - 621 | - |
dc.relation.isPartOf | PARASITOLOGY INTERNATIONAL | - |
dc.citation.title | PARASITOLOGY INTERNATIONAL | - |
dc.citation.volume | 66 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 619 | - |
dc.citation.endPage | 621 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.subject.keywordPlus | ANTIMALARIAL ACTIVITY | - |
dc.subject.keywordPlus | PLASMODIUM-FALCIPARUM | - |
dc.subject.keywordPlus | METRONIDAZOLE | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | RESISTANT | - |
dc.subject.keywordPlus | STAGE | - |
dc.subject.keywordPlus | N-251 | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | N-89 | - |
dc.subject.keywordAuthor | Trichomonas vaginalis | - |
dc.subject.keywordAuthor | 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) | - |
dc.subject.keywordAuthor | 6-(1,2,6,7-Tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) | - |
dc.subject.keywordAuthor | Anti-trichomonal activity | - |
dc.subject.keywordAuthor | Endoperoxides | - |
dc.subject.keywordAuthor | Metronidazole-resistant isolate | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1383576917301824?via%3Dihub | - |
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