Positive surgical margin in robot-assisted radical prostatectomy: correlation with pathology findings and risk of biochemical recurrence
DC Field | Value | Language |
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dc.contributor.author | Jo, Jung-Ki | - |
dc.contributor.author | Hong, Sung-Kyu | - |
dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Zargar, Homayoun | - |
dc.contributor.author | Autorino, Riccardo | - |
dc.contributor.author | Lee, Sang-Eun | - |
dc.date.accessioned | 2022-07-13T04:36:00Z | - |
dc.date.available | 2022-07-13T04:36:00Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0393-2249 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151488 | - |
dc.description.abstract | BACKGROUND: To analyze the correlation of surgical margin status with other findings on final pathology and risk of biochemical recurrence (BCR) in patients undergoing robot-assisted radical prostatectomy (RALP). METHODS: Bundang Prostatectomy Database was reviewed to identify patients who underwent RARP from 2007 to 2011 and had a positive surgical margin (PSM) on final pathology. Pathology findings were reviewed. BCR-free survival was calculated using the Kaplan-Meier method. Cox univariable and multi-variable regression models were used to find the correlation between clinicopathologic factors and BCR. RESULTS: Eight hundred and fifteen patients were included in the analysis: 118 (14.48%) had apical positive margin, 152 (18.65%) had a positive margin in another site, and 545 (66.87%) had negative surgical margins. In patients with only apical PSM, stratified by clinical stage, Kaplan-Meier analysis demonstrated significant difference in BCR-free survival between the groups (log rank P< 0.001). Multivariable Cox proportional hazards model showed maximal percentage of positive core is the strongest predictor of BCR (HR=3.131, P< 0.001). Multivariable Cox proportional hazards model showed PSM is one of the powerful predictor of postoperative BCR (HR= 3.123, P< 0.001). CONCLUSIONS: PSM after RALP is one of the powerful predictor of BCR and apical PSM is relatively less powerful predictor of BCR. Maximal percentage of positive core is the most powerful preoperative predictors of BCR. Clinical stage and biopsy Gleason score are also associated with pathologic outcomes and BCR free survival rates in patients with positive apical margin only. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | EDIZIONI MINERVA MEDICA | - |
dc.title | Positive surgical margin in robot-assisted radical prostatectomy: correlation with pathology findings and risk of biochemical recurrence | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jo, Jung-Ki | - |
dc.identifier.doi | 10.23736/S0393-2249.17.02707-2 | - |
dc.identifier.scopusid | 2-s2.0-85026346069 | - |
dc.identifier.wosid | 000406388400009 | - |
dc.identifier.bibliographicCitation | MINERVA UROLOGICA E NEFROLOGICA, v.69, no.5, pp.493 - 500 | - |
dc.relation.isPartOf | MINERVA UROLOGICA E NEFROLOGICA | - |
dc.citation.title | MINERVA UROLOGICA E NEFROLOGICA | - |
dc.citation.volume | 69 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 493 | - |
dc.citation.endPage | 500 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | RETROPUBIC PROSTATECTOMY | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | SITE | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordPlus | RECOMMENDATIONS | - |
dc.subject.keywordPlus | SPECIMENS | - |
dc.subject.keywordPlus | LOCATION | - |
dc.subject.keywordAuthor | Prostate | - |
dc.subject.keywordAuthor | Prostatectomy | - |
dc.subject.keywordAuthor | Margins of excision | - |
dc.identifier.url | https://www.minervamedica.it/en/journals/minerva-urology-nephrology/article.php?cod=R19Y2017N05A0493 | - |
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