Programmed death ligand-1 and MET co-expression is a poor prognostic factor in gastric cancers after resection
DC Field | Value | Language |
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dc.contributor.author | Kwon, Mi Jung | - |
dc.contributor.author | Kim, Kab-Choong | - |
dc.contributor.author | Nam, Eun Sook | - |
dc.contributor.author | Cho, Seong Jin | - |
dc.contributor.author | Park, Hye-Rim | - |
dc.contributor.author | Min, Soo Kee | - |
dc.contributor.author | Seo, Jinwon | - |
dc.contributor.author | Choe, Ji-Young | - |
dc.contributor.author | Lee, Hye Kyung | - |
dc.contributor.author | Kang, Ho Suk | - |
dc.contributor.author | Min, Kyueng-Whan | - |
dc.date.accessioned | 2022-07-13T07:10:04Z | - |
dc.date.available | 2022-07-13T07:10:04Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151528 | - |
dc.description.abstract | Programmed death-ligand 1 (PD-L1) plays an essential protein for immune evasion, contributing to tumor development and progression. Recent studies have reported MET as an upregulator for PD-L1 overexpression through an oncogenic pathway. However, an association between PD-L1 expression with MET has not been reported in gastric cancer. The prognostic significance of PD-L1 and its association with Epstein-Barr virus (EBV), microsatellite instability (MSI), and mucin phenotype remain controversial. We performed in situ hybridization for EBV-encoded RNA and immunohistochemistry in tissue microarrays for 394 gastric cancers. A multiplex polymerase chain reaction with five quasimonomorphic markers was performed for MSI. PD-L1 expression was observed in 123 cases (31.2%), and clinicopathological features such as MET overexpression, high pT stage, and a lack of lymphatic invasion represent significant risk factors associated with PD-L1 overexpression in gastric cancers. No associations of EBV, MSI, or mucin phenotype with PD-L1 expression were statistically significant. PD-L1 expression was a strong indicator for worse overall survival (OS) but borderline significant in disease-free survival (DFS). A combined analysis of PD-L1 and MET expression indicated that the PD-L1+/MET+ subgroup showed the worst prognosis when compared to the PD-L1-/MET-subgroup, which had the best clinical outcome. Furthermore, PD-L1 overexpression exhibited poor prognosis in terms of both OS and DFS in EBV-negative, microsatellite stable, and intestinal mucin phenotype tumors. In conclusion, this is the first study to evaluate the overexpression of MET as a risk factor for PD-L1 positivity in gastric cancer tissue as well as the reliability and prognostic relevance of PD-L1/MET co-expression after surgery. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | Programmed death ligand-1 and MET co-expression is a poor prognostic factor in gastric cancers after resection | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Kyueng-Whan | - |
dc.identifier.doi | 10.18632/oncotarget.19390 | - |
dc.identifier.scopusid | 2-s2.0-85030835209 | - |
dc.identifier.wosid | 000412683900065 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.8, no.47, pp.82399 - 82414 | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 8 | - |
dc.citation.number | 47 | - |
dc.citation.startPage | 82399 | - |
dc.citation.endPage | 82414 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | DIFFERENTIATED-TYPE ADENOCARCINOMAS | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | CLINICAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | PD-L1 EXPRESSION | - |
dc.subject.keywordPlus | GENE AMPLIFICATION | - |
dc.subject.keywordPlus | PROTEIN EXPRESSION | - |
dc.subject.keywordPlus | C-MET | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | B7-H1 | - |
dc.subject.keywordPlus | CLASSIFICATIONS | - |
dc.subject.keywordAuthor | gastric cancer | - |
dc.subject.keywordAuthor | programmed death ligand-1 protein | - |
dc.subject.keywordAuthor | MET protein | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | microsatellite instability | - |
dc.identifier.url | https://www.oncotarget.com/article/19390/text/ | - |
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