Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4(+) T cells
DC Field | Value | Language |
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dc.contributor.author | Jang, Eunkyeong | - |
dc.contributor.author | Lee, Hye Rim | - |
dc.contributor.author | Lee, Geon Hee | - |
dc.contributor.author | Oh, Ah-Reum | - |
dc.contributor.author | Cha, Ji-Young | - |
dc.contributor.author | Igarashi, Kazuhiko | - |
dc.contributor.author | Youn, Jeehee | - |
dc.date.accessioned | 2022-07-13T12:03:48Z | - |
dc.date.available | 2022-07-13T12:03:48Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151720 | - |
dc.description.abstract | The transcription repressor Bach2 has been proposed as a regulator of T cell quiescence, but the underlying mechanism is not fully understood. Given the importance of interleukin-2 in T cell activation, we investigated whether Bach2 is a component of the network of factors that regulates interleukin-2 expression. In primary and transformed CD4(+) T cells, Bach2 overexpression counteracted T cell receptor/CD28-or PMA/ionomycin-driven induction of interleukin-2 expression, and silencing of Bach2 had the opposite effect. Luciferase and chromatin immunoprecipitation assays revealed that Bach2 binds to multiple Maf-recognition element-like sites on the interleukin-2 proximal promoter in a manner competitive with AP-1, and thereby represses AP-1-driven induction of interleukin-2 transcription. Thus, this study demonstrates that Bach2 is a direct repressor of the interleukin-2 gene in CD4(+) T cells during the immediate early phase of AP-driven activation, thereby playing an important role in the maintenance of immune quiescence in the steady state. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.title | Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4(+) T cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Youn, Jeehee | - |
dc.identifier.doi | 10.5483/BMBRep.2017.50.9.124 | - |
dc.identifier.scopusid | 2-s2.0-85030176264 | - |
dc.identifier.wosid | 000412955100007 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.50, no.9, pp.472 - 477 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 50 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 472 | - |
dc.citation.endPage | 477 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002265305 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | RISK LOCI | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Bach2 | - |
dc.subject.keywordAuthor | CD4(+) T cells | - |
dc.subject.keywordAuthor | IL-2 | - |
dc.subject.keywordAuthor | Repressor | - |
dc.identifier.url | https://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2017.50.9.124 | - |
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