한국인 뾰족콘딜로마 환자의 임상 및사람유두종바이러스 유전자형에 대한 분석Clinical Manifestations and Genotypes of Human Papillomavirus in Korean Patients with Condyloma Acuminatum
- Other Titles
- Clinical Manifestations and Genotypes of Human Papillomavirus in Korean Patients with Condyloma Acuminatum
- Authors
- 최현석; 서현민; 김정수; 유희준
- Issue Date
- Aug-2017
- Publisher
- 대한피부과학회
- Keywords
- Condyloma acuminatum; Human papillomavirus
- Citation
- 대한피부과학회지, v.55, no.7, pp.394 - 400
- Indexed
- SCOPUS
KCI
- Journal Title
- 대한피부과학회지
- Volume
- 55
- Number
- 7
- Start Page
- 394
- End Page
- 400
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151806
- ISSN
- 0494-4739
- Abstract
- Background: Condyloma acuminatum is a sexually transmitted disease (STD) associated with the human papillomavirus (HPV). Although it is a relatively common disease, there has been no epidemiological and clinical study of condyloma acuminatum performed in Korea since 1978.
Objective: We aimed to evaluate the clinical features of condyloma acuminatum in Korean patients, to identify the genotypes of HPV, as well as determine factors associated with recurrence of condyloma acuminatum.
Methods: We studied 80 patients (60 men and 20 women) diagnosed with condyloma acuminatum. We analyzed age, sex, duration of the disease, number and locations of lesions, underlying diseases and co-infection with STDs, treatment modalities, and number of relapses. Additionally, 26 patients were analyzed for HPV subtypes. We also evaluated factors affecting recurrence of condyloma.
Results: Mean age at the time of diagnosis was 36.9±17.7 years and mean duration of disease was 7.2±16.5 months. The most common sites of involvement were found to be the penile shaft in men and the labia majora in women. We observed that 28 patients showed relapse with a mean duration of 1.5±4.5 months. HPV genotyping revealed that type 6, 11, and 44 genotypes that are associated with a low risk of malignancy were detected in 76.9% of cases, and type 16, 18, 51, 52, and 66 genotypes associated with a high risk of malignancy were detected in 15.3% cases. A significant relationship was observed between the recurrence rates of condyloma acuminatum and the rates of co-infection with STDs and the number of lesions.
Conclusion: We report a recent epidemiological and clinical review analyzing genotypes of HPV in Korean patients presenting with condyloma acuminatum.
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