Development of Nephrolithiasis in Asymptomatic Hyperuricemia: A Cohort Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seolhye | - |
dc.contributor.author | Chang, Yoosoo | - |
dc.contributor.author | Yun, Kyung Eun | - |
dc.contributor.author | Jung, Hyun-Suk | - |
dc.contributor.author | Lee, Soo-Jin | - |
dc.contributor.author | Shin, Hocheol | - |
dc.contributor.author | Ryu, Seungho | - |
dc.date.accessioned | 2022-07-13T16:22:06Z | - |
dc.date.available | 2022-07-13T16:22:06Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 0272-6386 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151872 | - |
dc.description.abstract | Background: Although the association between gout and nephrolithiasis is well known, the relationship between asymptomatic hyperuricemia and the development of nephrolithiasis is largely unknown. Study Design: Cohort study. Setting & Participants: 239,331 Korean adults who underwent a health checkup examination during January 2002 to December 2014 and were followed up annually or biennially through December 2014. Predictor: Baseline serum uric acid levels of participants. Outcome: The development of nephrolithiasis during follow-up. Measurements: Nephrolithiasis is determined based on ultrasonographic findings. A parametric Cox model was used to estimate the adjusted HRs of nephrolithiasis according to serum uric acid level. Results: During 1,184,653.8 person-years of follow-up, 18,777 participants developed nephrolithiasis (incidence rate, 1.6/100 person-years). Elevated uric acid level was significantly associated with increased risk for nephrolithiasis in a dose-response manner (P for trend, 0.001) in men. This dose-response association was not observed in women. In male participants, multivariable-adjusted HRs for incident nephrolithiasis comparing uric acid levels of 6.0 to 6.9, 7.0 to 7.9, 8.0 to 8.9, 9.0 to 9.9, and $10.0 mg/dL with uric acid levels, 6.0 mg/dL were 1.06 (95% CI, 1.02-1.11), 1.11 (95% CI, 1.05-1.16), 1.21 (95% CI, 1.13-1.29), 1.31 (95% CI, 1.17-1.46), and 1.72 (95% CI, 1.44-2.06), respectively. This association was observed in all clinically relevant subgroups and persisted even after adjustment for homeostasis model assessment of insulin resistance and high-sensitivity C-reactive protein level. Limitations: Dietary information and computed tomographic diagnosis of nephrolithiasis were unavailable. Conclusions: In this large cohort study, increased serum uric acid level was modestly and independently associated with increased risk for the development of nephrolithiasis in a dose-response manner in apparently healthy men. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | W. B. Saunders Co., Ltd. | - |
dc.title | Development of Nephrolithiasis in Asymptomatic Hyperuricemia: A Cohort Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Soo-Jin | - |
dc.identifier.doi | 10.1053/j.ajkd.2017.01.053 | - |
dc.identifier.scopusid | 2-s2.0-85017455681 | - |
dc.identifier.wosid | 000406047500010 | - |
dc.identifier.bibliographicCitation | American Journal of Kidney Diseases, v.70, no.2, pp.173 - 181 | - |
dc.relation.isPartOf | American Journal of Kidney Diseases | - |
dc.citation.title | American Journal of Kidney Diseases | - |
dc.citation.volume | 70 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 173 | - |
dc.citation.endPage | 181 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | URIC-ACID | - |
dc.subject.keywordPlus | CALCIUM-OXALATE | - |
dc.subject.keywordPlus | KIDNEY-STONES | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | CLINICAL SPECTRUM | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | GOUT | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | EXCRETION | - |
dc.subject.keywordAuthor | Nephrolithiasis | - |
dc.subject.keywordAuthor | uric acid | - |
dc.subject.keywordAuthor | hyperuricemia | - |
dc.subject.keywordAuthor | cohort study | - |
dc.subject.keywordAuthor | risk factor | - |
dc.subject.keywordAuthor | urinary stones | - |
dc.subject.keywordAuthor | kidney stone | - |
dc.subject.keywordAuthor | abdominal ultrasound | - |
dc.subject.keywordAuthor | sex differences | - |
dc.subject.keywordAuthor | Korea | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0272638617305486?via%3Dihub | - |
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