TNF-α-induced Inflammation Stimulates Apolipoprotein-A4 via Activation of TNFR2 and NF-κB Signaling in Kidney Tubular Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyung Ho | - |
dc.contributor.author | Cho, Young In | - |
dc.contributor.author | Kim, Sook Young | - |
dc.contributor.author | Yoon, Young Eun | - |
dc.contributor.author | Kim, Kyung Sup | - |
dc.contributor.author | Hong, Sung Joon | - |
dc.contributor.author | Han, Woong Kyu | - |
dc.date.accessioned | 2022-07-13T18:32:30Z | - |
dc.date.available | 2022-07-13T18:32:30Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151903 | - |
dc.description.abstract | Apo-A4 expression was increased in tissues from chronic kidney disease (CKD) patients compared to that in normal kidney tissue. We determined the association of apo-A4 and its regulatory signals following acute kidney injury and elucidated the effects of apo-A4 on cell signaling pathways related to kidney injury in vitro and in vivo. Tumor necrosis factor (TNF)-α, which causes inflammatory cell injury, induced significantly increased expression of apo-A4 protein levels, and these levels were related to pro-inflammatory acute kidney injury in human kidney cells. Apo-A4 expression was also increased in experimented rat kidney tissues after ischemic reperfusion injury. The expression of tumor necrosis factor receptor (TNFR) 2 was increased in both kidney cell lines and experimented rat kidney tissues following acute kidney injury. The expression of apo-A4 and TNFR2 was increased upon treatment with TNF-α. Immunohistochemistry revealed positive apo-A4 and TNFR2 staining in ischemic reperfusion injury rat kidneys compared with levels in the sham operation kidneys. After neutralization of TNF-α, NF-κB expression was only observed in the cytoplasm by immunofluorescence. Therefore, the apo-A4 expression is increased by stimulation of injured kidney cells with TNF-α and that these effects occur via a TNFR2-NFκB complex. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | TNF-α-induced Inflammation Stimulates Apolipoprotein-A4 via Activation of TNFR2 and NF-κB Signaling in Kidney Tubular Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Young Eun | - |
dc.identifier.doi | 10.1038/s41598-017-08785-2 | - |
dc.identifier.scopusid | 2-s2.0-85027865064 | - |
dc.identifier.wosid | 000407980000110 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.7, pp.1 - 9 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 7 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | ACUTE-RENAL-FAILURE | - |
dc.subject.keywordPlus | A-IV | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | MILD | - |
dc.subject.keywordPlus | MICE | - |
dc.identifier.url | https://www.nature.com/articles/s41598-017-08785-2 | - |
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