Rapid preparation and single-cell analysis of concentrated blood smears using a high-throughput separator and a microfabricated grid film
DC Field | Value | Language |
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dc.contributor.author | You, Dongwon | - |
dc.contributor.author | Oh, Sein | - |
dc.contributor.author | Kim, Byeongyeon | - |
dc.contributor.author | Hahn, Young Ki | - |
dc.contributor.author | Choi, Sung young | - |
dc.date.accessioned | 2022-07-13T20:00:37Z | - |
dc.date.available | 2022-07-13T20:00:37Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 0021-9673 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151957 | - |
dc.description.abstract | Cytological examination of peripheral white blood cells inhomogeneously distributed on a blood smear is currently limited by the low abundance and random sampling of the target cells. To address the challenges, we present a new approach to prepare and analyze concentrated blood smears by rapidly enriching white blood cells up to 32-fold with 92% recovery on average at a high throughput (1mL/min) using a deterministic migration-based separator and by systematically analyzing a large number of the cells distributed over a blood slide using a microfabricated grid film. We anticipate that our approach will improve the clinical utility of blood smear tests, while offering the capability to detect rare cell populations. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Rapid preparation and single-cell analysis of concentrated blood smears using a high-throughput separator and a microfabricated grid film | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Sung young | - |
dc.identifier.doi | 10.1016/j.chroma.2017.05.047 | - |
dc.identifier.scopusid | 2-s2.0-85019671016 | - |
dc.identifier.wosid | 000404491500017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CHROMATOGRAPHY A, v.1507, pp.141 - 148 | - |
dc.relation.isPartOf | JOURNAL OF CHROMATOGRAPHY A | - |
dc.citation.title | JOURNAL OF CHROMATOGRAPHY A | - |
dc.citation.volume | 1507 | - |
dc.citation.startPage | 141 | - |
dc.citation.endPage | 148 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular BiologyChemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular BiologyChemistry | - |
dc.subject.keywordPlus | ACTIVATED ENDOTHELIAL-CELLSPERIPHERAL-BLOODCOUNTINDICATORSPIPETTEDISEASE | - |
dc.subject.keywordAuthor | Blood smears | - |
dc.subject.keywordAuthor | Cytochemical analysis | - |
dc.subject.keywordAuthor | Deterministic migration | - |
dc.subject.keywordAuthor | Microfabricated grid film | - |
dc.subject.keywordAuthor | Microfluidics. | - |
dc.identifier.url | https://linkinghub.elsevier.com/retrieve/pii/S0021967317307653 | - |
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