Development of efficient adeno-associated virus (AAV)-mediated gene delivery system with a phytoactive material for targeting human melanoma cells
DC Field | Value | Language |
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dc.contributor.author | Lee, John Hwan | - |
dc.contributor.author | Kim, Yoojin | - |
dc.contributor.author | Yoon, Ye-Eun | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.contributor.author | Oh, Seong-Geun | - |
dc.contributor.author | Jang, Jae-Hyung | - |
dc.contributor.author | Kim, Eunmi | - |
dc.date.accessioned | 2022-07-14T00:53:59Z | - |
dc.date.available | 2022-07-14T00:53:59Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1871-6784 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152065 | - |
dc.description.abstract | We exploited the emerging potential of gene therapy strategies to design a powerful therapeutic system that combines two key components AAV vector and [6]-gingerol. In this study, we created an AAV2 construct expressing the proapoptotic protein BIM, which uses HSPG as its primary receptor, to target HSPG-overexpressing melanoma cells. This combination treatment showed promising results in vitro, inducing apoptosis in human melanoma cells. This new platform technology will make a significant contribution to numerous therapeutic applications, most notably for melanoma, including overcoming resistance to conventional anticancer therapies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Development of efficient adeno-associated virus (AAV)-mediated gene delivery system with a phytoactive material for targeting human melanoma cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Seong-Geun | - |
dc.identifier.doi | 10.1016/j.nbt.2017.02.001 | - |
dc.identifier.scopusid | 2-s2.0-85015339492 | - |
dc.identifier.wosid | 000401203500005 | - |
dc.identifier.bibliographicCitation | NEW BIOTECHNOLOGY, v.37, pp.194 - 199 | - |
dc.relation.isPartOf | NEW BIOTECHNOLOGY | - |
dc.citation.title | NEW BIOTECHNOLOGY | - |
dc.citation.volume | 37 | - |
dc.citation.startPage | 194 | - |
dc.citation.endPage | 199 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | HEPARAN-SULFATE PROTEOGLYCAN | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | VECTORS | - |
dc.subject.keywordPlus | BIM | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | Adeno-associated virus | - |
dc.subject.keywordAuthor | Pro-apoptotic gene | - |
dc.subject.keywordAuthor | Gene delivery system | - |
dc.subject.keywordAuthor | Melanoma | - |
dc.subject.keywordAuthor | [6]-Gingerol | - |
dc.identifier.url | https://linkinghub.elsevier.com/retrieve/pii/S187167841632369X | - |
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