Interaction between Trichomonas vaginalis and the Prostate Epithelium
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jung-Hyun | - |
dc.contributor.author | Han, Ik-Hwan | - |
dc.contributor.author | Kim, Sang-Su | - |
dc.contributor.author | Park, Soon-Jung | - |
dc.contributor.author | Min, Duk-Young | - |
dc.contributor.author | Ahn, Myoung-Hee | - |
dc.contributor.author | Ryu, Jae-Sook | - |
dc.date.accessioned | 2022-07-14T07:28:44Z | - |
dc.date.available | 2022-07-14T07:28:44Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152579 | - |
dc.description.abstract | Most men infected with Trichomonas vaginalis are asymptomatic and can remain undiagnosed and untreated. This has been hypothesized to result in chronic persistent prostatic infection. Adhesion of the protozoan organisms to mucosal cells is considered a first and prerequisite step for T. vaginalis infection. Adhesion of T. vaginalis to prostate epithelial cells has not yet been observed; however, there are several reports about inflammation of prostate epithelial cells induced by T. vaginalis. The aim of this study was to investigate whether adhesion and cytotoxicity of T. vaginalis are involved in inflammation of prostate epithelial cells. When RWPE-1 cells were infected with T. vaginalis (1: 0.4 or 1: 4), adhesion of T. vaginalis continuously increased for 24 hr or 3 hr, respectively. The cytotoxicity of prostate epithelial cells infected with T. vaginalis (RWPE-1: T. vaginalis= 1: 0.4) increased at 9 hr; at an infection ratio of 1: 4, cytotoxicity increased after 3 hr. When the RWPE-1 to T. vaginalis ratio was 1: 0.4 or 1: 4, production of IL-1 beta, IL-6, CCL2, and CXCL8 also increased. Epithelial-mesenchymal transition (EMT) was verified by measuring decreased E-cadherin and increased vimentin expression at 24 hr and 48 hr. Taken together, the results indicate that T. vaginalis adhered to prostate epithelial cells, causing cytotoxicity, pro-inflammatory cytokine production, and EMT. Our findings suggest for the first time that T. vaginalis may induce inflammation via adhesion to normal prostate epithelial cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI | - |
dc.title | Interaction between Trichomonas vaginalis and the Prostate Epithelium | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, Jae-Sook | - |
dc.identifier.doi | 10.3347/kjp.2017.55.2.213 | - |
dc.identifier.scopusid | 2-s2.0-85019021954 | - |
dc.identifier.wosid | 000402802800016 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PARASITOLOGY, v.55, no.2, pp.213 - 218 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.citation.volume | 55 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 213 | - |
dc.citation.endPage | 218 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002221985 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.subject.keywordPlus | MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordAuthor | Trichomonas vaginalis | - |
dc.subject.keywordAuthor | epithelial cell | - |
dc.subject.keywordAuthor | cell adhesion | - |
dc.subject.keywordAuthor | inflammation | - |
dc.identifier.url | https://www.parasitol.kr/journal/view.php?doi=10.3347/kjp.2017.55.2.213 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.