TRPV1 Regulates Stress Responses through HDAC2
DC Field | Value | Language |
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dc.contributor.author | Wang, Sung Eun | - |
dc.contributor.author | Ko, Seung Yeon | - |
dc.contributor.author | Jo, Sungsin | - |
dc.contributor.author | Choi, Miyeon | - |
dc.contributor.author | Lee, Seung Hoon | - |
dc.contributor.author | Jo, Hye-Ryeong | - |
dc.contributor.author | Seo, Jee Young | - |
dc.contributor.author | Lee, Sang Hoon | - |
dc.contributor.author | Kim, Yong-Seok | - |
dc.contributor.author | Jung, Sung Jun | - |
dc.contributor.author | Son, Hyeon | - |
dc.date.accessioned | 2022-07-14T10:13:44Z | - |
dc.date.available | 2022-07-14T10:13:44Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152626 | - |
dc.description.abstract | Stress causes changes in neurotransmission in the brain, thereby influencing stress-induced behaviors. However, it is unclear how neurotransmission systems orchestrate stress responses at the molecular and cellular levels. Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel involved mainly in pain sensation, affects mood and neuroplasticity in the brain, where its role is poorly understood. Here, we show that Trpv1-deficient (Trpv1(-/-)) mice are more stress resilient than control mice after chronic unpredictable stress. We also found that glucocorticoid receptor (GR)-mediated histone deacetylase 2 (HDAC) 2 expression and activity are reduced in the Trpv1(-/-) mice and that HDAC2-regulated, cell-cycle- and neuroplasticity-related molecules are altered. Hippocampal knockdown of TRPV1 had similar effects, and its behavioral effects were blocked by HDAC2 overexpression. Collectively, our findings indicate that HDAC2 is a molecular link between TRPV1 activity and stress responses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.title | TRPV1 Regulates Stress Responses through HDAC2 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Seok | - |
dc.contributor.affiliatedAuthor | Jung, Sung Jun | - |
dc.contributor.affiliatedAuthor | Son, Hyeon | - |
dc.identifier.doi | 10.1016/j.celrep.2017.03.050 | - |
dc.identifier.scopusid | 2-s2.0-85017313833 | - |
dc.identifier.wosid | 000401132600015 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, v.19, no.2, pp.401 - 412 | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.citation.title | CELL REPORTS | - |
dc.citation.volume | 19 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 401 | - |
dc.citation.endPage | 412 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | MEDIATED GENE-TRANSCRIPTION | - |
dc.subject.keywordPlus | GLUCOCORTICOID-RECEPTOR | - |
dc.subject.keywordPlus | DENTATE GYRUS | - |
dc.subject.keywordPlus | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject.keywordPlus | ENDOCANNABINOID SYSTEM | - |
dc.subject.keywordPlus | PSYCHIATRIC-DISORDERS | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | CAPSAICIN RECEPTOR | - |
dc.subject.keywordPlus | BEHAVIORAL DESPAIR | - |
dc.subject.keywordPlus | MEMORY FORMATION | - |
dc.subject.keywordAuthor | TRPV1 | - |
dc.subject.keywordAuthor | behavior | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | stress | - |
dc.subject.keywordAuthor | HDAC2 | - |
dc.subject.keywordAuthor | GR | - |
dc.subject.keywordAuthor | hippocampus | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2211124717303960?via%3Dihub | - |
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