Mitochondrial DNA copy number augments performance of A₁C and oral glucose tolerance testing in the prediction of type 2 diabetes
DC Field | Value | Language |
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dc.contributor.author | Cho, Seong Beom | - |
dc.contributor.author | Koh, InSong | - |
dc.contributor.author | Nam, Hye-Young | - |
dc.contributor.author | Jeon, Jae-Pil | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Han, Bok-Ghee | - |
dc.date.accessioned | 2022-07-14T12:36:18Z | - |
dc.date.available | 2022-07-14T12:36:18Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152783 | - |
dc.description.abstract | Here, we tested the performance of the mitochondrial DNA copy number (mtDNA-CN) in predicting future type 2 diabetes (n = 1108). We used the baseline clinical data (age, sex, body mass index, waist-to-hip ratio, systolic and diastolic blood pressure) and the mtDNA-CN, hemoglobin A(1c) (A(1)C) levels and results of oral glucose tolerance test (OGTT) including fasting plasma glucose, 1-hour glucose, and 2-hour glucose levels, to predict future diabetes. We built a prediction model using the baseline data and the diabetes status at biannual follow-up of 8 years. The mean area under curve (AUC) for all followups of the full model including all variables was 0.92 +/- 0.04 (mean +/- standard deviation), while that of the model excluding the mtDNA-CN was 0.90 +/- 0.03. The sensitivity of the f4ull model was much greater than that of the model not including mtDNA-CN: the mean sensitivities of the model with and without mtDNA-CN were 0.60 +/- 0.06 and 0.53 +/- 0.04, respectively. We found that the mtDNA-CN of peripheral leukocytes is a biomarker that augments the predictive power for future diabetes of A1C and OGTT. We believe that these results could provide invaluable information for developing strategies for the management of diabetes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Mitochondrial DNA copy number augments performance of A₁C and oral glucose tolerance testing in the prediction of type 2 diabetes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koh, InSong | - |
dc.identifier.doi | 10.1038/srep43203 | - |
dc.identifier.scopusid | 2-s2.0-85014422708 | - |
dc.identifier.wosid | 000395370000001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.7, pp.1 - 8 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 7 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | FASTING PLASMA-GLUCOSE | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | HBA1C | - |
dc.subject.keywordPlus | RISK | - |
dc.identifier.url | https://www.nature.com/articles/srep43203 | - |
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