Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donationopen access
- Authors
- Lee, Mark Hong; Jang, Joo Hyeon; Min, Hyojin J.; Jang, H. I.; Nah, J. H.; Lyu, Chuhljoo; Han, Kyoungsup; Won, Jong-ho; Lee, Young-ho; Chong, So-young; Mun, Yeung Chul; Lee, Won-sik; Kim, Seokjin; Kim, Inho
- Issue Date
- Feb-2017
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- BONE MARROW TRANSPLANTATION, v.52, no.2, pp.258 - 263
- Indexed
- SCIE
SCOPUS
- Journal Title
- BONE MARROW TRANSPLANTATION
- Volume
- 52
- Number
- 2
- Start Page
- 258
- End Page
- 263
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152947
- DOI
- 10.1038/bmt.2016.260
- ISSN
- 0268-3369
- Abstract
- We performed a retrospective study of 1868 consecutive unrelated donors to predict the risk factors related to general discomfort, limitations in activities of daily living (ADLs) and intention of a second donation in hematopoietic stem cell (HSC) donation. General discomfort and limitations in ADLs were assessed by numerical measurement (scores of 0-10) and donor's intention of a second donation by yes or no reply. The post-donation questionnaires were completed within 48 h after HSC collection and at 1 week, 4 weeks, and 4 months thereafter. Predictors of general discomfort included female sex (P < 0.0001), bone marrow (BM) collection (Po0.0001) or PBSC collection through a central line (CL; P = 0.0349), 2-day collection (P = 0.0150) and negative or undetermined intention of a second donation on day 1 (P < 0.0001). Predictors of limitations in ADLs included age group of 30-39 years (P = 0.0046), female sex (P< 0.0001), BM collection (P < 0.0001) or PBSC collection through a CL (Po0.0001) and negative or undetermined intention of a second donation on day 1 (P < 0.0001). The only predictor of positive intention of a second donation was male sex (P = 0.0007). Age, sex and collection method and period should be considered risk factors when unrelated HSC donation is performed.
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