Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chandrasekaran, Arun Pandian | - |
dc.contributor.author | Suresh, Bharathi | - |
dc.contributor.author | Kim, Hyongbum (Henry) | - |
dc.contributor.author | Kim, Kye-Seong | - |
dc.contributor.author | Ramakrishna, Suresh | - |
dc.date.accessioned | 2022-07-14T20:37:55Z | - |
dc.date.available | 2022-07-14T20:37:55Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1066-5099 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153068 | - |
dc.description.abstract | Post-translational modification by ubiquitin molecules is a key regulatory process for stem cell fate determination. Ubiquitination and deubiquitination are the major cellular processes used to balance the protein turnover of several transcription factors that regulate stem cell differentiation. Deubiquitinating enzymes (DUBs), which facilitate the processing of ubiquitin, significantly influence stem cell fate choices. Specifically, DUBs play a critical regulatory role during development by directing the production of new specialized cells. This review focuses on the regulatory role of DUBs in various cellular processes, including stem cell pluripotency and differentiation, adult stem cell signaling, cellular reprogramming, spermatogenesis, and oogenesis. Specifically, the identification of interactions of DUBs with core transcription factors has provided new insight into the role of DUBs in regulating stem cell fate determination. Thus, DUBs have emerged as key pharmacologic targets in the search to develop highly specific agents to treat various illnesses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Kye-Seong | - |
dc.contributor.affiliatedAuthor | Ramakrishna, Suresh | - |
dc.identifier.doi | 10.1002/stem.2446 | - |
dc.identifier.scopusid | 2-s2.0-85007092816 | - |
dc.identifier.wosid | 000391966700003 | - |
dc.identifier.bibliographicCitation | STEM CELLS, v.35, no.1, pp.9 - 16 | - |
dc.relation.isPartOf | STEM CELLS | - |
dc.citation.title | STEM CELLS | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9 | - |
dc.citation.endPage | 16 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.subject.keywordPlus | UBIQUITIN-PROTEASOME SYSTEM | - |
dc.subject.keywordPlus | C-TERMINAL HYDROLASE | - |
dc.subject.keywordPlus | NEURAL PROGENITORS | - |
dc.subject.keywordPlus | PROTEIN BREAKDOWN | - |
dc.subject.keywordPlus | MALE-FERTILITY | - |
dc.subject.keywordPlus | Y-CHROMOSOME | - |
dc.subject.keywordPlus | GERM-CELLS | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | SPERMATOGENESIS | - |
dc.subject.keywordPlus | USP22 | - |
dc.subject.keywordAuthor | Post-translational modification | - |
dc.subject.keywordAuthor | Ubiquitination | - |
dc.subject.keywordAuthor | Deubiquitination | - |
dc.subject.keywordAuthor | Deubiquitinating enzymes | - |
dc.subject.keywordAuthor | Pluripotency | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordAuthor | Spermatogenesis | - |
dc.subject.keywordAuthor | Oogenesis | - |
dc.identifier.url | https://stemcellsjournals.onlinelibrary.wiley.com/doi/10.1002/stem.2446 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.