Differential Progression of Midbrain Atrophy in Parkinsonism: Longitudinal MRI Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Minho | - |
dc.contributor.author | Yang, Hyunwoo | - |
dc.contributor.author | Kim, Younsoo | - |
dc.contributor.author | Youn, Jinyoung | - |
dc.contributor.author | Park, Jongkyu | - |
dc.contributor.author | Huh, Young Eun | - |
dc.contributor.author | Kim, Hee-Tae | - |
dc.contributor.author | Cho, Jin Whan | - |
dc.date.accessioned | 2022-07-14T23:37:35Z | - |
dc.date.available | 2022-07-14T23:37:35Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1660-2854 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153241 | - |
dc.description.abstract | Aims: To elucidate different patterns of progression of midbrain atrophy in patients with Richardson's syndrome (RS), progressive supranuclear palsy-parkinsonism (PSP-P), and Parkinson's disease (PD) using magnetic resonance imaging (MRI)-based visual rating indexes. Methods: We recruited 12 patients with PSP-RS, 12 with PSP-P, and 23 with PD for whom MRIs had been followed up for at least 2 years (mean +/- SD, 4.9 +/- 1.6 years) after the initial MRI. MRI-based visual rating indexes were used to estimate midbrain atrophy, including the ratio of the pontine to midbrain tegmental areas (P/M ratio) on a midsagittal image, the length between the interpeduncular fossa and the center of the cerebral aqueduct at the midmammillary-body level (M-TEGM) on axial images, and the morning glory sign. Results: Initially, there were no differences in MRI-based visual rating indexes between PSP-P and PD, while PSP-RS showed a higher P/M ratio and lower M-TEGM compared with PSP-P and PD. In PD, the P/M ratio and M-TEGM remained stable with disease progression. However, the extent of changes between initial and follow-up indexes was similarly greater for both PSP-RS and PSP-P than for PD. Finally, PSP-P showed a higher P/M ratio and lower M-TEGM compared with PD in the follow-up, while PSP-RS still exhibited the most profound changes. Conclusions: Midbrain atrophy progresses differentially in patients with PSP-RS, PSP-P, and PD. Longitudinal measurements of midbrain atrophy using MRI-based visual rating indexes can help distinguish patients with PSP-P from those with PSP-RS and PD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.title | Differential Progression of Midbrain Atrophy in Parkinsonism: Longitudinal MRI Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hee-Tae | - |
dc.identifier.doi | 10.1159/000448174 | - |
dc.identifier.scopusid | 2-s2.0-84988354719 | - |
dc.identifier.wosid | 000387973800004 | - |
dc.identifier.bibliographicCitation | NEURODEGENERATIVE DISEASES, v.17, no.1, pp.31 - 37 | - |
dc.relation.isPartOf | NEURODEGENERATIVE DISEASES | - |
dc.citation.title | NEURODEGENERATIVE DISEASES | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 37 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | SUPRANUCLEAR PALSY-PARKINSONISM | - |
dc.subject.keywordPlus | NINDS NEUROPATHOLOGIC CRITERIA | - |
dc.subject.keywordPlus | MULTIPLE SYSTEM ATROPHY | - |
dc.subject.keywordPlus | RICHARDSONS-SYNDROME | - |
dc.subject.keywordPlus | CLINICAL-DIAGNOSIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PSP | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | DIAMETER | - |
dc.subject.keywordAuthor | Progressive supranuclear palsy-parkinsonism | - |
dc.subject.keywordAuthor | Richardson&apos | - |
dc.subject.keywordAuthor | s syndrome | - |
dc.subject.keywordAuthor | Longitudinal magnetic resonance imaging | - |
dc.subject.keywordAuthor | Midbrain atrophy | - |
dc.identifier.url | https://www.karger.com/Article/FullText/448174 | - |
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