Antimelanogenic Efficacy of Melasolv (3,4,5-Trimethoxycinnamate Thymol Ester) in Melanocytes and Three-Dimensional Human Skin Equivalent
DC Field | Value | Language |
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dc.contributor.author | Lee, John Hwan | - |
dc.contributor.author | Lee, Eun-Soo | - |
dc.contributor.author | Bae, Il-Hong | - |
dc.contributor.author | Hwang, Jeong-Ah | - |
dc.contributor.author | Kim, Se-Hwa | - |
dc.contributor.author | Kim, Dae-Yong | - |
dc.contributor.author | Park, Nok-Hyun | - |
dc.contributor.author | Rho, Ho Sik | - |
dc.contributor.author | Kim, Yong Jin | - |
dc.contributor.author | Oh, Seong-Geun | - |
dc.contributor.author | Lee, Chang Seok | - |
dc.date.accessioned | 2022-07-14T23:38:34Z | - |
dc.date.available | 2022-07-14T23:38:34Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1660-5527 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153255 | - |
dc.description.abstract | Background/Aims: Excessive melanogenesis often causes unaesthetic hyperpigmentation. In a previous report, our group introduced a newly synthesized depigmentary agent, Melasolv (TM) (3,4,5-trimethoxycinnamate thymol ester). In this study, we demonstrated the significant whitening efficacy of Melasolv using various melanocytes and human skin equivalents as in vitro experimental systems. Methods: The depigmentary effect of Melasolv was tested in melan-a cells (immortalized normal murine melanocytes), alpha-melanocytestimulating hormone (alpha-MSH)-stimulated B16 murine melanoma cells, primary normal human melanocytes (NHMs), and human skin equivalent (MelanoDerm). The whitening efficacy of Melasolv was further demonstrated by photography, time-lapse microscopy, Fontana-Masson (F&M) staining, and 2-photon microscopy. Results: Melasolv significantly inhibited melanogenesis in the melan-a and alpha-MSH-stimulated B16 cells. In human systems, Melasolv also clearly showed a whitening effect in NHMs and human skin equivalent, reflecting a decrease in melanin content. F&M staining and 2-photon microscopy revealed that Melasolv suppressed melanin transfer into multiple epidermal layers from melanocytes as well as melanin synthesis in human skin equivalent. Conclusion: Our study showed that Melasolv clearly exerts a whitening effect on various melanocytes and human skin equivalent. These results suggest the possibility that Melasolv can be used as a depigmentary agent to treat pigmentary disorders as well as an active ingredient in cosmetics to increase whitening efficacy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.title | Antimelanogenic Efficacy of Melasolv (3,4,5-Trimethoxycinnamate Thymol Ester) in Melanocytes and Three-Dimensional Human Skin Equivalent | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Seong-Geun | - |
dc.identifier.doi | 10.1159/000477356 | - |
dc.identifier.scopusid | 2-s2.0-85021675337 | - |
dc.identifier.wosid | 000407177700003 | - |
dc.identifier.bibliographicCitation | SKIN PHARMACOLOGY AND PHYSIOLOGY, v.30, no.4, pp.190 - 196 | - |
dc.relation.isPartOf | SKIN PHARMACOLOGY AND PHYSIOLOGY | - |
dc.citation.title | SKIN PHARMACOLOGY AND PHYSIOLOGY | - |
dc.citation.volume | 30 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 190 | - |
dc.citation.endPage | 196 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | MELANOMA-CELLS | - |
dc.subject.keywordAuthor | Melasolv | - |
dc.subject.keywordAuthor | Melanogenesis | - |
dc.subject.keywordAuthor | Depigmentary agent | - |
dc.subject.keywordAuthor | Three-dimensional human skin equivalent | - |
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