Expression Pattern of Smad4/GATA3 as a Predictor of Survival in Invasive Ductal Carcinoma of the Breast
DC Field | Value | Language |
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dc.contributor.author | Min, Kyueng-Whan | - |
dc.contributor.author | Kim, Dong-Hoon | - |
dc.contributor.author | Do, Sung-Im | - |
dc.contributor.author | Chae, Seoung Wan | - |
dc.contributor.author | Kim, Kyungeun | - |
dc.contributor.author | Sohn, Jin Hee | - |
dc.contributor.author | Lee, Hyun Joo | - |
dc.contributor.author | Do, In-Gu | - |
dc.contributor.author | Pyo, Jung-Soo | - |
dc.contributor.author | Kim, Yuil | - |
dc.contributor.author | Kim, Dong Hyun | - |
dc.contributor.author | Yang, Jung-Ho | - |
dc.contributor.author | Lee, Sang-Jo | - |
dc.contributor.author | Oh, Young Ha | - |
dc.contributor.author | Oh, Sukjoong | - |
dc.contributor.author | Choi, Seon Hyeong | - |
dc.contributor.author | Park, Yong Lai | - |
dc.contributor.author | Park, Chan Heun | - |
dc.contributor.author | Kim, Eun-Kyung | - |
dc.contributor.author | Kwon, Mi Jung | - |
dc.contributor.author | Seo, Jinwon | - |
dc.date.accessioned | 2022-07-14T23:39:44Z | - |
dc.date.available | 2022-07-14T23:39:44Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1015-2008 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153269 | - |
dc.description.abstract | Background: Smad4 and GATA3 proteins are known prognostic markers in various cancers. Smad4 is a mediator linked to both tumour suppression and progression. GATA3 is a regulator of development and morphogenesis of the mammary gland. We assessed and compared the predictive performance of Smad4 and GATA3 for clinical outcomes in patients with breast cancer. Methods: The combined expression pattern based on Smad4+/- and GATA3+/- was evaluated by immunostaining using breast cancer tissue microarray, and the relationships between protein expression and clinicopathological variables were analysed. Results: Smad4 expression was only associated with an ill-defined tumour border, whereas GATA3 was associated with several good prognostic factors. On analysis of combined markers, there was a significant difference in the expression of fascin (an important factor for cancer invasiveness) between the Smad4+/GATA3- and Smad4-/GATA3+ groups. Smad4+/GATA3- was correlated with worse clinicopathological parameters, relapse-free survival (RFS), and overall survival (OS), compared to Smad4-/GATA3+. Conclusion: Combined markers of Smad4/GATA3 showed a superior performance compared to single markers for predicting RFS and OS in patients with breast cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.title | Expression Pattern of Smad4/GATA3 as a Predictor of Survival in Invasive Ductal Carcinoma of the Breast | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Kyueng-Whan | - |
dc.contributor.affiliatedAuthor | Oh, Young Ha | - |
dc.identifier.doi | 10.1159/000449428 | - |
dc.identifier.scopusid | 2-s2.0-85015667570 | - |
dc.identifier.wosid | 000401217200003 | - |
dc.identifier.bibliographicCitation | PATHOBIOLOGY, v.84, no.3, pp.130 - 138 | - |
dc.relation.isPartOf | PATHOBIOLOGY | - |
dc.citation.title | PATHOBIOLOGY | - |
dc.citation.volume | 84 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 130 | - |
dc.citation.endPage | 138 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR GENE | - |
dc.subject.keywordPlus | GUIDELINE RECOMMENDATIONS | - |
dc.subject.keywordPlus | AMERICAN SOCIETY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SMAD4 | - |
dc.subject.keywordPlus | FASCIN | - |
dc.subject.keywordPlus | GATA3 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordAuthor | Smad4 protein | - |
dc.subject.keywordAuthor | GATA3 protein | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.identifier.url | https://www.karger.com/Article/FullText/449428 | - |
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