Roles and epigenetic regulation of epithelial-mesenchymal transition and its transcription factors in cancer initiation and progression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jeong-Yeon | - |
dc.contributor.author | Kong, Gu | - |
dc.date.accessioned | 2022-07-14T23:57:04Z | - |
dc.date.available | 2022-07-14T23:57:04Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 1420-682X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153414 | - |
dc.description.abstract | The epithelial-mesenchymal transition (EMT) is a crucial developmental process by which epithelial cells undergo a mesenchymal phenotypic change. During EMT, epigenetic mechanisms including DNA methylation and histone modifications are involved in the regulation of EMT-related genes. The epigenetic gene silencing of the epithelial marker E-cadherin has been well characterized. In particular, three major transcriptional repressors of E-cadherin, Snail, ZEB, and Twist families, also known as EMT-inducing transcription factors (EMT-TFs), play a crucial role in this process by cooperating with multiple epigenetic modifiers. Furthermore, recent studies have identified the novel epigenetic modifiers that control the expression of EMT-TFs, and these modifiers have emerged as critical regulators of cancer development and as novel therapeutic targets for human cancer. In this review, the diverse functions of EMT-TFs in cancer progression, the cooperative mechanisms of EMT-TFs with epigenetic modifiers, and epigenetic regulatory roles for the expression of EMT-TFs will be discussed. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.title | Roles and epigenetic regulation of epithelial-mesenchymal transition and its transcription factors in cancer initiation and progression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jeong-Yeon | - |
dc.contributor.affiliatedAuthor | Kong, Gu | - |
dc.identifier.doi | 10.1007/s00018-016-2313-z | - |
dc.identifier.scopusid | 2-s2.0-84979703525 | - |
dc.identifier.wosid | 000387491800006 | - |
dc.identifier.bibliographicCitation | CELLULAR AND MOLECULAR LIFE SCIENCES, v.73, no.24, pp.4643 - 4660 | - |
dc.relation.isPartOf | CELLULAR AND MOLECULAR LIFE SCIENCES | - |
dc.citation.title | CELLULAR AND MOLECULAR LIFE SCIENCES | - |
dc.citation.volume | 73 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 4643 | - |
dc.citation.endPage | 4660 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | E-CADHERIN EXPRESSION | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | - |
dc.subject.keywordPlus | REPRESSES E-CADHERIN | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | HISTONE DEMETHYLASE | - |
dc.subject.keywordPlus | DNA METHYLATION | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordAuthor | EMT | - |
dc.subject.keywordAuthor | EMT transcription factor | - |
dc.subject.keywordAuthor | Human cancer | - |
dc.subject.keywordAuthor | Epigenetics | - |
dc.subject.keywordAuthor | Chromatin | - |
dc.subject.keywordAuthor | Histone modification | - |
dc.subject.keywordAuthor | DNA methylation | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00018-016-2313-z | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.