SUBRETINAL FIBROSIS AFTER ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY IN EYES WITH MYOPIC CHOROIDAL NEOVASCULARIZATION
DC Field | Value | Language |
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dc.contributor.author | Ahn, Seong Joon | - |
dc.contributor.author | Park, Kyu Hyung | - |
dc.contributor.author | Woo, Se Joon | - |
dc.date.accessioned | 2022-07-15T04:19:23Z | - |
dc.date.available | 2022-07-15T04:19:23Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 0275-004X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153616 | - |
dc.description.abstract | Purpose: To assess the incidence and risk factors of subretinal fibrosis and their impact on visual outcome in eyes with myopic CNV. Methods: Medical records of 72 eyes treated with antivascular endothelial growth factor (anti-VEGF) therapy in a pro re nata regimen for myopic CNV that followed up for more than 1 year were retrospectively reviewed. The presence of subretinal fibrosis after anti-VEGF therapy was determined using both fundus photographs and optical coherence tomography. The incidence and risk factors of subretinal fibrosis were evaluated, and best-corrected visual acuity was compared between the eyes with and without subretinal fibrosis. Results: The incidences of subretinal fibrosis during the 1-year and whole follow-up period were 31.9% and 36.1%, respectively. Occurrence of subretinal fibrosis was associated with frequent CNV recurrence (P = 0.005) and poor baseline best-corrected visual acuity (P = 0.044) in a Cox proportional hazard model. Anatomically, the eyes with subretinal fibrosis showed more frequent progression of chorioretinal atrophy (95.7% vs. 71.4%, P = 0.027) and less frequent photoreceptor recovery (17.4% vs. 65.3%, P < 0.001) after anti-VEGF therapy. Occurrence of subretinal fibrosis was associated with poor vision at baseline (P = 0.011) and the final visit (P = 0.008) when compared with the findings in the nonoccurrence group. Conclusion: Development of subretinal fibrosis after anti-VEGF therapy was common in eyes with myopic CNV and was associated with CNV recurrence. Myopic eyes with subretinal fibrosis show progressive chorioretinal atrophy and poor visual outcome. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | SUBRETINAL FIBROSIS AFTER ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY IN EYES WITH MYOPIC CHOROIDAL NEOVASCULARIZATION | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn, Seong Joon | - |
dc.identifier.doi | 10.1097/IAE.0000000000001043 | - |
dc.identifier.scopusid | 2-s2.0-84968548120 | - |
dc.identifier.wosid | 000387079800021 | - |
dc.identifier.bibliographicCitation | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, v.36, no.11, pp.2140 - 2149 | - |
dc.relation.isPartOf | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | - |
dc.citation.title | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | - |
dc.citation.volume | 36 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2140 | - |
dc.citation.endPage | 2149 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | OPTICAL COHERENCE TOMOGRAPHY | - |
dc.subject.keywordPlus | MACULAR DEGENERATION | - |
dc.subject.keywordPlus | INTRAVITREAL RANIBIZUMAB | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | PATHOLOGICAL MYOPIA | - |
dc.subject.keywordPlus | VISUAL OUTCOMES | - |
dc.subject.keywordPlus | NATURAL-HISTORY | - |
dc.subject.keywordPlus | BEVACIZUMAB | - |
dc.subject.keywordPlus | THICKNESS | - |
dc.subject.keywordPlus | VASCULOPATHY | - |
dc.subject.keywordAuthor | antivascular endothelial growth factor | - |
dc.subject.keywordAuthor | choroidal neovascularization | - |
dc.subject.keywordAuthor | pathologic myopia | - |
dc.subject.keywordAuthor | subretinal fibrosis | - |
dc.subject.keywordAuthor | visual outcome | - |
dc.identifier.url | https://journals.lww.com/retinajournal/Fulltext/2016/11000/SUBRETINAL_FIBROSIS_AFTER_ANTIVASCULAR_ENDOTHELIAL.14.aspx | - |
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