The Effect of Osteopontin and an Osteopontin-Derived Synthetic Peptide Coating on Osseointegration of Implants in a Canine Model
- Authors
- Fiorellini, Joseph P.; Glindmann, Sven; Salcedo, Jairo; Weber, Hans-Peter; Park, Chang-Joo; Sarmiento, Hector L.
- Issue Date
- Nov-2016
- Publisher
- Quintessence Publishing Company
- Citation
- International Journal of Periodontics and Restorative Dentistry, v.36, no.6, pp.E88 - E94
- Indexed
- SCIE
SCOPUS
- Journal Title
- International Journal of Periodontics and Restorative Dentistry
- Volume
- 36
- Number
- 6
- Start Page
- E88
- End Page
- E94
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153630
- DOI
- 10.11607/prd.2830
- ISSN
- 0198-7569
- Abstract
- Osteopontin (OPN) and an OPN-derived synthetic peptide, OC-1016, have demonstrated their potential to enhance osseointegration in vitro. The purpose of this study was to evaluate bone-to-implant contact (BIC) and surrounding bone density (BD) of implants coated with either recombinant human OPN (rhOPN) or OC-1016 as compared with noncoated titanium plasma sprayed (TPS) surface in a canine model. Histomorphometric analysis revealed that at 4 weeks, % BIC and % BD of coated implants were signiicantly higher than those of noncoated TPS implants. At 12 weeks, % BIC of coated implants was also signiicantly higher than that of noncoated implants; however, there was no statistically signiicant difference in % BD. The rhOPN and OC-1016 were concluded to be capable of signiicantly accelerating the early stage of osseointegration and bone healing around implants.
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