Radiogenomic correlation in lung adenocarcinoma with epidermal growth factor receptor mutations: Imaging features and histological subtypes
DC Field | Value | Language |
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dc.contributor.author | Hong, Su Jin | - |
dc.contributor.author | Kim, Tae Jung | - |
dc.contributor.author | Choi, Yo Won | - |
dc.contributor.author | Park, Jeong-Soo | - |
dc.contributor.author | Chung, Jin-Haeng | - |
dc.contributor.author | Lee, Kyung Won | - |
dc.date.accessioned | 2022-07-15T05:36:04Z | - |
dc.date.available | 2022-07-15T05:36:04Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153849 | - |
dc.description.abstract | Objectives To correlate imaging features of resected lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation and the IASLC/ATS/ERS classification histological subtypes. Methods In 250 consecutive patients with resected lung adenocarcinoma, EGFR mutation status was correlated with demographics, imaging features including ground-glass opacity (GGO) proportion and the IASLC/ATS/ERS classification histological subtypes. Results EGFR mutations were significantly more frequent in women (54.5 % vs. 38.1 %, p = 0.011) and in never-smokers (54.7 % vs. 35.3 %, p = 0.003). GGO proportion was significantly higher in tumours with EGFR mutation than in those without (30.3 ± 33.8 % vs. 19.0 ± 29.3 %, p = 0.005). EGFR mutation was significantly more frequent in tumours with GGO ≥ 50 % and tumours with any GGO (p = 0.026 and 0.008, respectively). Adenocarcinomas with exon 19 or 21 mutation showed significantly higher GGO proportion than that in EGFR wild-type tumours (p = 0.009 and 0.029, respectively). Absence of GGO was an independent predictor of negative EGFR mutation (odds ratio, 1.81; 95 % confidence interval, 1.16–3.04; p = 0.018). Conclusions GGO proportion in adenocarcinomas with EGFR mutation was significantly higher than that in EGFR wild-type tumours, and the absence of GGO on CT was an independent predictor of negative EGFR mutation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Radiogenomic correlation in lung adenocarcinoma with epidermal growth factor receptor mutations: Imaging features and histological subtypes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Su Jin | - |
dc.contributor.affiliatedAuthor | Choi, Yo Won | - |
dc.identifier.doi | 10.1007/s00330-015-4196-z | - |
dc.identifier.scopusid | 2-s2.0-84954558938 | - |
dc.identifier.wosid | 000383625200040 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, v.26, no.10, pp.3660 - 3668 | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.citation.title | EUROPEAN RADIOLOGY | - |
dc.citation.volume | 26 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 3660 | - |
dc.citation.endPage | 3668 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | GROUND-GLASS OPACITY | - |
dc.subject.keywordPlus | BRONCHIOLOALVEOLAR PATHOLOGICAL SUBTYPE | - |
dc.subject.keywordPlus | RESOLUTION COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | LYMPH-NODE METASTASIS | - |
dc.subject.keywordPlus | PULMONARY ADENOCARCINOMA | - |
dc.subject.keywordPlus | GENE MUTATION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | EGFR | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordAuthor | Computed tomography (CT) | - |
dc.subject.keywordAuthor | Lung | - |
dc.subject.keywordAuthor | Adenocarcinoma | - |
dc.subject.keywordAuthor | Epidermal growth factor receptor (EGFR) | - |
dc.subject.keywordAuthor | Mutation | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00330-015-4196-z | - |
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