Multiplex bioimaging of piRNA molecular pathway-regulated theragnostic effects in a single breast cancer cell using a piRNA molecular beacon
DC Field | Value | Language |
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dc.contributor.author | Lee, Youn Jung | - |
dc.contributor.author | Moon, Sung Ung | - |
dc.contributor.author | Park, Min Geun | - |
dc.contributor.author | Jung, Woon Yong | - |
dc.contributor.author | Park, Yong Keun | - |
dc.contributor.author | Song, Sung Kyu | - |
dc.contributor.author | Ryu, Je Gyu | - |
dc.contributor.author | Lee, Yong Seung | - |
dc.contributor.author | Heo, Hye Jung | - |
dc.contributor.author | Gu, Ha Na | - |
dc.contributor.author | Cho, Su Jeong | - |
dc.contributor.author | Ali, Bahy A. | - |
dc.contributor.author | Al-Khedhairy, Abdulaziz A. | - |
dc.contributor.author | Lee, Ilkyun | - |
dc.contributor.author | Kim, Soonhag | - |
dc.date.accessioned | 2022-07-15T07:09:24Z | - |
dc.date.available | 2022-07-15T07:09:24Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153944 | - |
dc.description.abstract | Recently, PIWI-interacting small non-coding RNAs (piRNAs) have emerged as novel cancer biomarkers candidate because of their high expression level in various cancer types and role in the control of tumor suppressor genes. In this study, a novel breast cancer theragnostics probe based on a single system targeting the piRNA-36026 (piR-36026) molecular pathway was developed using a piR-36026 molecular beacon (MB). The piR-36026 MB successfully visualized endogenous piR-36026 biogenesis, which is highly expressed in MCF7 cells (a human breast cancer cell line), and simultaneously inhibited piR-36026-mediated cancer progression in vitro and in vivo. We discovered two tumor suppressor proteins, SERPINA1 and LRAT, that were directly regulated as endogenous piR-36026 target genes in MCF7 cells. Furthermore, multiplex bioimaging of a single MCF7 cell following treatment with piR-36026 MB clearly visualized the direct molecular interaction of piRNA-36026 with SERPINAI or LRAT and subsequent molecular therapeutic responses including caspase-3 and PI in the nucleus. Lee, YJ | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Multiplex bioimaging of piRNA molecular pathway-regulated theragnostic effects in a single breast cancer cell using a piRNA molecular beacon | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Woon Yong | - |
dc.identifier.doi | 10.1016/j.biomaterials.2016.05.052 | - |
dc.identifier.scopusid | 2-s2.0-84973349376 | - |
dc.identifier.wosid | 000379632500013 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.101, pp.143 - 155 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 101 | - |
dc.citation.startPage | 143 | - |
dc.citation.endPage | 155 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | ALPHA-1-ANTITRYPSIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | RNAS | - |
dc.subject.keywordPlus | ALPHA(1)-ANTITRYPSIN | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordAuthor | Molecular beacon | - |
dc.subject.keywordAuthor | piRNA-36026 | - |
dc.subject.keywordAuthor | Cancer theragnosis | - |
dc.subject.keywordAuthor | Multiplex bioimaging | - |
dc.subject.keywordAuthor | Molecular pathway | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0142961216302435?via%3Dihub | - |
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