A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging
DC Field | Value | Language |
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dc.contributor.author | Moon, Won-Jin | - |
dc.contributor.author | Park, Ju-Yeon | - |
dc.contributor.author | Yun, Won-Sung | - |
dc.contributor.author | Jeon, Ji Yeong | - |
dc.contributor.author | Moon, Yeon Sil | - |
dc.contributor.author | Kim, Heejin | - |
dc.contributor.author | Kwak, Ki-Chang | - |
dc.contributor.author | Lee, Jong Min | - |
dc.contributor.author | Han, Seol-Heui | - |
dc.date.accessioned | 2022-07-15T07:13:44Z | - |
dc.date.available | 2022-07-15T07:13:44Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154004 | - |
dc.description.abstract | Objective: Neuromelanin loss of substantia nigra (SN) can be visualized as a T1 signal reduction on T1-weighted high-resolution imaging. We investigated whether volumetric analysis of T1 hyperintensity for SN could be used to differentiate between Parkinson's disease dementia (PDD), Alzheimer's disease (AD) and age-matched controls. Materials and Methods: This retrospective study enrolled 10 patients with PDD, 18 patients with AD, and 13 age-matched healthy elderly controls. MR imaging was performed at 3 tesla. To measure the T1 hyperintense area of SN, we obtained an axial thin section high-resolution T1-weighted fast spin echo sequence. The volumes of interest for the T1 hyperintense SN were drawn onto heavily T1-weighted FSE sequences through midbrain level, using the MIPAV software. The measurement differences were tested using the Kruskal-Wallis test followed by a post hoc comparison. Results: A comparison of the three groups showed significant differences in terms of volume of T1 hyperintensity (p < 0.001, Bonferroni corrected). The volume of T1 hyperintensity was significantly lower in PDD than in AD and normal controls (p < 0.005, Bonferroni corrected). However, the volume of T1 hyperintensity was not different between AD and normal controls (p = 0.136, Bonferroni corrected). Conclusion: The volumetric measurement of the T1 hyperintensity of SN can be an imaging marker for evaluating neuromelanin loss in neurodegenerative diseases and a differential in PDD and AD cases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN RADIOLOGICAL SOC | - |
dc.title | A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jong Min | - |
dc.identifier.doi | 10.3348/kjr.2016.17.5.633 | - |
dc.identifier.scopusid | 2-s2.0-84984914960 | - |
dc.identifier.wosid | 000383357700006 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, v.17, no.5, pp.633 - 640 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF RADIOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF RADIOLOGY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 633 | - |
dc.citation.endPage | 640 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002152430 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | CLINICAL-DIAGNOSIS | - |
dc.subject.keywordPlus | LOCUS-CERULEUS | - |
dc.subject.keywordPlus | SENSITIVE MRI | - |
dc.subject.keywordPlus | ANATOMY | - |
dc.subject.keywordPlus | IRON | - |
dc.subject.keywordAuthor | Neuromelanin | - |
dc.subject.keywordAuthor | High-resolution T1-weighted imaging | - |
dc.subject.keywordAuthor | Magnetic resonance | - |
dc.subject.keywordAuthor | Parkinsonian disorders | - |
dc.subject.keywordAuthor | Dementia | - |
dc.subject.keywordAuthor | Alzheimer disease | - |
dc.subject.keywordAuthor | Substantia nigra | - |
dc.identifier.url | https://www.kjronline.org/DOIx.php?id=10.3348/kjr.2016.17.5.633 | - |
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