Intron retention-dependent gene regulation in Cryptococcus neoformans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gonzalez-Hilarion, Sara | - |
dc.contributor.author | Paulet, Damien | - |
dc.contributor.author | Lee, Kyung-Tae | - |
dc.contributor.author | Hon, Chung-Chau | - |
dc.contributor.author | Lechat, Pierre | - |
dc.contributor.author | Mogensen, Estelle | - |
dc.contributor.author | Moyrand, Frederique | - |
dc.contributor.author | Proux, Caroline | - |
dc.contributor.author | Barboux, Rony | - |
dc.contributor.author | Bussotti, Giovanni | - |
dc.contributor.author | Hwang, Jungwook | - |
dc.contributor.author | Coppee, Jean-Yves | - |
dc.contributor.author | Bahn, Yong-Sun | - |
dc.contributor.author | Janbon, Guilhem | - |
dc.date.accessioned | 2022-07-15T13:43:31Z | - |
dc.date.available | 2022-07-15T13:43:31Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154219 | - |
dc.description.abstract | The biological impact of alternative splicing is poorly understood in fungi, although recent studies have shown that these microorganisms are usually intron-rich. In this study, we re-annotated the genome of C. neoformans var. neoformans using RNA-Seq data. Comparison with C. neoformans var. grubii revealed that more than 99% of ORF-introns are in the same exact position in the two varieties whereas UTR-introns are much less evolutionary conserved. We also confirmed that alternative splicing is very common in C. neoformans, affecting nearly all expressed genes. We also observed specific regulation of alternative splicing by environmental cues in this yeast. However, alternative splicing does not appear to be an efficient method to diversify the C. neoformans proteome. Instead, our data suggest the existence of an intron retention-dependent mechanism of gene expression regulation that is not dependent on NMD. This regulatory process represents an additional layer of gene expression regulation in fungi and provides a mechanism to tune gene expression levels in response to any environmental modification. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Intron retention-dependent gene regulation in Cryptococcus neoformans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Jungwook | - |
dc.identifier.doi | 10.1038/srep32252 | - |
dc.identifier.scopusid | 2-s2.0-84984985524 | - |
dc.identifier.wosid | 000382237800001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.6, pp.1 - 13 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 6 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NONSENSE-MEDIATED DECAY | - |
dc.subject.keywordPlus | MESSENGER-RNA DECAY | - |
dc.subject.keywordPlus | DIFFERENTIAL EXPRESSION ANALYSIS | - |
dc.subject.keywordPlus | NUCLEAR RETENTION | - |
dc.subject.keywordPlus | GENOME | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordPlus | SURVEILLANCE | - |
dc.subject.keywordPlus | TRANSCRIPTS | - |
dc.subject.keywordPlus | VIRULENCE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.identifier.url | https://www.nature.com/articles/srep32252 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.