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Insulin Signaling Augments eIF4E-Dependent Nonsense-Mediated mRNA Decay in Mammalian Cells

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dc.contributor.authorPark, Jungyun-
dc.contributor.authorAhn, Seyoung-
dc.contributor.authorJayabalan, Aravinth K.-
dc.contributor.authorOhn, Takbum-
dc.contributor.authorKoh, Hyun Chul-
dc.contributor.authorHwang, Jungwook-
dc.date.accessioned2022-07-15T14:31:32Z-
dc.date.available2022-07-15T14:31:32Z-
dc.date.created2021-05-12-
dc.date.issued2016-07-
dc.identifier.issn1874-9399-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154311-
dc.description.abstractNonsense-mediated mRNA decay (NMD) modulates the level of mRNA harboring a premature termination codon (PTC) in a translation-dependent manner. Inhibition of translation is known to impair NMD; however, few studies have investigated the correlation between enhanced translation and increased NMD. Here, we demonstrate that insulin signaling events increase translation, leading to an increase in NMD of eIF4E-bound transcripts. We provide evidence that (i) insulin-mediated enhancement of translation augments NMD and rapamycin abrogates this enhancement; (ii) an increase in AKT phosphorylation due to inhibition of PTEN facilitates NMD; (iii) insulin stimulation increases the binding of up-frameshift factor 1 (UPF1), most likely to eIF4E-bound PTC-containing transcripts; and (iv) insulin stimulation induces the colocalization of UPF1 and eIF4E in processing bodies. These results illustrate how extracellular signaling promotes the removal of eIF4E-bound NMD targets.-
dc.language영어-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE BV-
dc.titleInsulin Signaling Augments eIF4E-Dependent Nonsense-Mediated mRNA Decay in Mammalian Cells-
dc.typeArticle-
dc.contributor.affiliatedAuthorKoh, Hyun Chul-
dc.contributor.affiliatedAuthorHwang, Jungwook-
dc.identifier.doi10.1016/j.bbagrm.2015.12.006-
dc.identifier.scopusid2-s2.0-84953438885-
dc.identifier.wosid000378959500007-
dc.identifier.bibliographicCitationBIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, v.1859, no.7, pp.896 - 905-
dc.relation.isPartOfBIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS-
dc.citation.titleBIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS-
dc.citation.volume1859-
dc.citation.number7-
dc.citation.startPage896-
dc.citation.endPage905-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.subject.keywordPlusPTEN TUMOR-SUPPRESSOR-
dc.subject.keywordPlusTRANSLATION INITIATION-
dc.subject.keywordPlusPROCESSING BODIES-
dc.subject.keywordPlus3&apos-
dc.subject.keywordPlusUTRS-
dc.subject.keywordPlusNMD FACTORS-
dc.subject.keywordPlusUPF1-
dc.subject.keywordPlusCOMPLEX-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordAuthorPI3K/AKT/mTOR-
dc.subject.keywordAuthorInsulin-
dc.subject.keywordAuthorNMD-
dc.subject.keywordAuthorTranslation-
dc.subject.keywordAuthorProcessing body-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1874939915002709?via%3Dihub-
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서울 의생명공학전문대학원 > 서울 의생명과학과 > 1. Journal Articles
서울 의과대학 > 서울 약리학교실 > 1. Journal Articles

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