Insulin Signaling Augments eIF4E-Dependent Nonsense-Mediated mRNA Decay in Mammalian Cells
DC Field | Value | Language |
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dc.contributor.author | Park, Jungyun | - |
dc.contributor.author | Ahn, Seyoung | - |
dc.contributor.author | Jayabalan, Aravinth K. | - |
dc.contributor.author | Ohn, Takbum | - |
dc.contributor.author | Koh, Hyun Chul | - |
dc.contributor.author | Hwang, Jungwook | - |
dc.date.accessioned | 2022-07-15T14:31:32Z | - |
dc.date.available | 2022-07-15T14:31:32Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.issn | 1874-9399 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154311 | - |
dc.description.abstract | Nonsense-mediated mRNA decay (NMD) modulates the level of mRNA harboring a premature termination codon (PTC) in a translation-dependent manner. Inhibition of translation is known to impair NMD; however, few studies have investigated the correlation between enhanced translation and increased NMD. Here, we demonstrate that insulin signaling events increase translation, leading to an increase in NMD of eIF4E-bound transcripts. We provide evidence that (i) insulin-mediated enhancement of translation augments NMD and rapamycin abrogates this enhancement; (ii) an increase in AKT phosphorylation due to inhibition of PTEN facilitates NMD; (iii) insulin stimulation increases the binding of up-frameshift factor 1 (UPF1), most likely to eIF4E-bound PTC-containing transcripts; and (iv) insulin stimulation induces the colocalization of UPF1 and eIF4E in processing bodies. These results illustrate how extracellular signaling promotes the removal of eIF4E-bound NMD targets. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Insulin Signaling Augments eIF4E-Dependent Nonsense-Mediated mRNA Decay in Mammalian Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koh, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Hwang, Jungwook | - |
dc.identifier.doi | 10.1016/j.bbagrm.2015.12.006 | - |
dc.identifier.scopusid | 2-s2.0-84953438885 | - |
dc.identifier.wosid | 000378959500007 | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, v.1859, no.7, pp.896 - 905 | - |
dc.relation.isPartOf | BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | - |
dc.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | - |
dc.citation.volume | 1859 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 896 | - |
dc.citation.endPage | 905 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | PTEN TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | TRANSLATION INITIATION | - |
dc.subject.keywordPlus | PROCESSING BODIES | - |
dc.subject.keywordPlus | 3&apos | - |
dc.subject.keywordPlus | UTRS | - |
dc.subject.keywordPlus | NMD FACTORS | - |
dc.subject.keywordPlus | UPF1 | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordAuthor | PI3K/AKT/mTOR | - |
dc.subject.keywordAuthor | Insulin | - |
dc.subject.keywordAuthor | NMD | - |
dc.subject.keywordAuthor | Translation | - |
dc.subject.keywordAuthor | Processing body | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1874939915002709?via%3Dihub | - |
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