Comparison of Iohexol-380 and Iohexol-350 for Coronary CT Angiography: A Multicenter, Randomized, Double-Blind Phase 3 Trial
DC Field | Value | Language |
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dc.contributor.author | Park, Eun-Ah | - |
dc.contributor.author | Lee, Whal | - |
dc.contributor.author | Kang, Doo Kyoung | - |
dc.contributor.author | Kim, Sung Jin | - |
dc.contributor.author | Kim, Young-Ju | - |
dc.contributor.author | Kim, Yookyung | - |
dc.contributor.author | Sung, Yon Mi | - |
dc.contributor.author | Song, Soon-Young | - |
dc.contributor.author | Oh, Yu-Whan | - |
dc.contributor.author | Yong, Hwan Seok | - |
dc.contributor.author | Lee, Heon | - |
dc.contributor.author | Jeon, Eui-Yong | - |
dc.contributor.author | Jin, Gong-Yong | - |
dc.contributor.author | Choi, Byoung Wook | - |
dc.contributor.author | Choi, Sang-Il | - |
dc.date.accessioned | 2022-07-15T16:59:37Z | - |
dc.date.available | 2022-07-15T16:59:37Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154676 | - |
dc.description.abstract | Objective This multi-center, randomized, double-blind, phase 3 trial was conducted to compare the safety and efficacy of contrast agents iohexol-380 and iohexol-350 for coronary CT angiography in healthy subjects. Materials and Methods Volunteers were randomized to receive 420 mgI/kg of either iohexol-350 or iohexol-380 using a flow rate of 4 mL/sec. All adverse events were recorded. Two blinded readers independently reviewed the CT images and conflicting results were resolved by a third reader. Luminal attenuations (ascending aorta, left main coronary artery, and left ventricle) in Hounsfield units (HUs) and image quality on a 4-point scale were calculated. Results A total of 225 subjects were given contrast media (115 with iohexol-380 and 110 with iohexol-350). There was no difference in number of adverse drug reactions between groups: 75 events in 56 (48.7%) of 115 subjects in the iohexol-380 group vs. 74 events in 51 (46.4%) of 110 subjects in the iohexol-350 group (p = 0.690). No severe adverse drug reactions were recorded. Neither group showed an increase in serum creatinine. Significant differences in mean density between the groups was found in the ascending aorta: 375.8 ± 71.4 HU with iohexol-380 vs. 356.3 ± 61.5 HU with iohexol-350 (p = 0.030). No significant differences in image quality scores between both groups were observed for all three anatomic evaluations (all, p > 0.05). Conclusion Iohexol-380 provides improved enhancement of the ascending aorta and similar attenuation of the coronary arteries without any increase in adverse drug reactions, as compared with iohexol-350 using an identical amount of total iodine. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN RADIOLOGICAL SOC | - |
dc.title | Comparison of Iohexol-380 and Iohexol-350 for Coronary CT Angiography: A Multicenter, Randomized, Double-Blind Phase 3 Trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Soon-Young | - |
dc.identifier.doi | 10.3348/kjr.2016.17.3.330 | - |
dc.identifier.scopusid | 2-s2.0-84964265526 | - |
dc.identifier.wosid | 000375889600003 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, v.17, no.3, pp.330 - 338 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF RADIOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF RADIOLOGY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 330 | - |
dc.citation.endPage | 338 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002112432 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | CONCENTRATION CONTRAST-MEDIA | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | IODINE-CONCENTRATION | - |
dc.subject.keywordPlus | IMAGE QUALITY | - |
dc.subject.keywordPlus | IOMEPROL 400 | - |
dc.subject.keywordPlus | CARDIAC CT | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | PRINCIPLES | - |
dc.subject.keywordPlus | ATTENUATION | - |
dc.subject.keywordPlus | RATIONALE | - |
dc.subject.keywordAuthor | Coronary arteries | - |
dc.subject.keywordAuthor | Contrast media | - |
dc.subject.keywordAuthor | Contrast materials | - |
dc.subject.keywordAuthor | Drug safety | - |
dc.subject.keywordAuthor | Image quality enhancement | - |
dc.identifier.url | https://www.kjronline.org/DOIx.php?id=10.3348/kjr.2016.17.3.330 | - |
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