Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm
DC Field | Value | Language |
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dc.contributor.author | Yoon, Hyuk | - |
dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Shin, Cheol Min | - |
dc.contributor.author | Lee, Hye Seung | - |
dc.contributor.author | Kim, Bo Kyoung | - |
dc.contributor.author | Kang, Gyeong Hoon | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Lee, Dong Ho | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.date.accessioned | 2022-07-15T18:10:20Z | - |
dc.date.available | 2022-07-15T18:10:20Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154999 | - |
dc.description.abstract | Background/Aims: To identify the risk factors for meta-chronous gastric neoplasms in patients who underwent an endoscopic resection of a gastric neoplasm. Methods: We prospectively collected clinicopathologic data and measured the methylation levels of NANDI, THBD, APC, and MOS in the gastric mucosa by methylation-specific real-time polymerase chain reaction in patients who underwent endoscopic resection of gastric neoplasms. Results: A total of 257 patients with gastric neoplasms (113 low-grade dysplasias, 25 high-grade dysplasias, and 119 early gastric cancers) were enrolled. Metachronous gastric neoplasm developed in 7.4% of patients during a mean follow-up of 52 months. The 5-year cumulative incidence of metachronous gastric neoplasm was 4.8%. Multivariate analysis showed that moderate/severe corpus intestinal metaplasia and family history of gastric cancer were independent risk factors for metachronous gastric neoplasm development; the hazard ratios were 4.12 (95% confidence interval [CI], 1.23 to 13.87; p=0.022) and 3.52 (95% CI, 1.09 to 11.40; p=0.036), respectively. The methylation level of MOS was significantly elevated in patients with metachronous gastric neoplasms compared age- and sex matched patients without metachronous gastric neoplasms (p=0.020). Conclusions: In patients who underwent endoscopic resection of gastric neoplasms, moderate/severe corpus intestinal metaplasia and a family history of gastric cancer were independent risk factors for metachronous gastric neoplasm, and MOS was significantly hypermethylated in patients with metachronous gastric neoplasms. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.title | Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jung Mogg | - |
dc.identifier.doi | 10.5009/gnl14472 | - |
dc.identifier.scopusid | 2-s2.0-84960490862 | - |
dc.identifier.wosid | 000371851900010 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, v.10, no.2, pp.228 - 236 | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.citation.title | GUT AND LIVER | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 228 | - |
dc.citation.endPage | 236 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002089654 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI ERADICATION | - |
dc.subject.keywordPlus | ABERRANT DNA METHYLATION | - |
dc.subject.keywordPlus | INTESTINAL METAPLASIA | - |
dc.subject.keywordPlus | CLINICOPATHOLOGICAL CHARACTERISTICS | - |
dc.subject.keywordPlus | PREDICTING DEVELOPMENT | - |
dc.subject.keywordPlus | ATROPHIC GASTRITIS | - |
dc.subject.keywordPlus | EPIGENETIC FIELD | - |
dc.subject.keywordPlus | SOUTH-KOREA | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | Risk factors | - |
dc.subject.keywordAuthor | Therapeutics | - |
dc.identifier.url | https://www.gutnliver.org/journal/view.html?doi=10.5009/gnl14472 | - |
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