Meta analysis identifies a novel susceptibility locus associated with heel bone strength in the Korean population
DC Field | Value | Language |
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dc.contributor.author | Hwang, Joo-Yeon | - |
dc.contributor.author | Kim, Young Jin | - |
dc.contributor.author | Choi, Bo Youl | - |
dc.contributor.author | Kim, Bong-Jo | - |
dc.contributor.author | Han, Bok-Ghee | - |
dc.date.accessioned | 2022-07-15T18:11:23Z | - |
dc.date.available | 2022-07-15T18:11:23Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 8756-3282 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155008 | - |
dc.description.abstract | Introduction Calcaneal quantitative ultrasound has been recognized as a non-invasive method for evaluation of bone strength and prediction of osteoporotic fracture. Methods To extend a thorough genetic catalog for osteoporotic bone properties, we performed a genome-wide association study (rural cohort I, n = 1895) of speed of sound (SOS) using the 1000 genome-based imputation in the discovery stage and then carried out in silico lookups (rural cohort II and III, n = 2,967) and de novo genotyping (rural cohort IV, n = 4,296) in the replication stage. Results In the combined meta-analysis (n = 9,158), we identified a novel variant associated with SOS (rs2445771 in the GLDN gene, P = 2.27 × 10− 9) reaching genome-wide significance in the Korean population. We further demonstrated that allele-specific regulatory modifications found to be associated with functional enrichments by ENCODE annotations. Conclusion: Our findings could provide additional insights into understanding of genetic and epigenetic regulations on bone metabolism. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Meta analysis identifies a novel susceptibility locus associated with heel bone strength in the Korean population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Bo Youl | - |
dc.identifier.doi | 10.1016/j.bone.2015.12.005 | - |
dc.identifier.scopusid | 2-s2.0-84951114803 | - |
dc.identifier.wosid | 000370914600006 | - |
dc.identifier.bibliographicCitation | BONE, v.84, pp.47 - 51 | - |
dc.relation.isPartOf | BONE | - |
dc.citation.title | BONE | - |
dc.citation.volume | 84 | - |
dc.citation.startPage | 47 | - |
dc.citation.endPage | 51 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | MINERAL DENSITY | - |
dc.subject.keywordPlus | FRACTURE RISK | - |
dc.subject.keywordPlus | QUANTITATIVE ULTRASOUND | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | RANVIER | - |
dc.subject.keywordPlus | OSTEOPOROSIS | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | GLIOMEDIN | - |
dc.subject.keywordAuthor | GWAS | - |
dc.subject.keywordAuthor | Meta | - |
dc.subject.keywordAuthor | Osteoporosis | - |
dc.subject.keywordAuthor | SOS | - |
dc.subject.keywordAuthor | Epigenetic | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S8756328215004275?via%3Dihub | - |
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