Analysis of the association between host genetics, smoking, and sputum microbiota in healthy humans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Mi Young | - |
dc.contributor.author | Yoon, Hyo Shin | - |
dc.contributor.author | Rho, Mina | - |
dc.contributor.author | Sung, Joohon | - |
dc.contributor.author | Song, Yun-Mi | - |
dc.contributor.author | Lee, Kayoung | - |
dc.contributor.author | Ko, GwangPyo | - |
dc.date.accessioned | 2022-07-15T18:19:37Z | - |
dc.date.available | 2022-07-15T18:19:37Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155049 | - |
dc.description.abstract | Recent studies showing clear differences in the airway microbiota between healthy and diseased individuals shed light on the importance of the airway microbiota in health. Here, we report the associations of host genetics and lifestyles such as smoking, alcohol consumption, and physical activity with the composition of the sputum microbiota using 16S rRNA gene sequence data generated from 257 sputum samples of Korean twin-family cohort. By estimating the heritability of each microbial taxon, we found that several taxa, including Providencia and Bacteroides, were significantly influenced by host genetic factors. Smoking had the strongest effect on the overall microbial community structure among the tested lifestyle factors. The abundances of Veillonella and Megasphaera were higher in current-smokers, and increased with the pack-year value and the Fagerstrom Test of Nicotine Dependence (FTND) score. In contrast, Haemophilus decreased with the pack-year of smoking and the FTND score. Co-occurrence network analysis showed that the taxa were clustered according to the direction of associations with smoking, and that the taxa influenced by host genetics were found together. These results demonstrate that the relationships among sputum microbial taxa are closely associated with not only smoking but also host genetics. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Analysis of the association between host genetics, smoking, and sputum microbiota in healthy humans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rho, Mina | - |
dc.identifier.doi | 10.1038/srep23745 | - |
dc.identifier.scopusid | 2-s2.0-84962888095 | - |
dc.identifier.wosid | 000373091700001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.6, pp.1 - 9 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 6 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | DIVERSITY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | COMMUNITIES | - |
dc.subject.keywordPlus | SAMPLES | - |
dc.subject.keywordPlus | KOREA | - |
dc.subject.keywordPlus | TWIN | - |
dc.identifier.url | https://www.nature.com/articles/srep23745 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.