Interaction of Wnt5a with Notch1 is Critical for the Pathogenesis of Psoriasis
DC Field | Value | Language |
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dc.contributor.author | Kim, Jeong Eun | - |
dc.contributor.author | Bang, Seung Hyun | - |
dc.contributor.author | Choi, Jee Ho | - |
dc.contributor.author | Kim, Chang Deok | - |
dc.contributor.author | Won, Chong Hyun | - |
dc.contributor.author | Lee, Mi Woo | - |
dc.contributor.author | Chang, Sung Eun | - |
dc.date.accessioned | 2022-07-15T18:29:52Z | - |
dc.date.available | 2022-07-15T18:29:52Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 1013-9087 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155163 | - |
dc.description.abstract | Background: Psoriasis is characterized by uncontrolled hyperproliferation, aberrant differentiation, and dermal infiltration of immune cells. Recent studies have reported that Wnt5a and Notch1 signaling are altered in psoriatic skin lesions. Objective: We aimed to investigate the interaction of Wnt5a with Notch 1 with respect to inflammation-mediated epidermal hyperproliferation in psoriasis. Methods: Expression of Wnt5a and Notch1 signaling-related proteins were examined in psoriatic skin biopsies. Wnt5a was upregulated in human keratinocytes by treating the cells with its recombinant form (rWnt5a). Results: In psoriatic lesions, expression of Wnt5a increased while that of Notch1 decreased when compared to that in non-lesional and normal skin. Treatment with rWnt5a increased the proliferation of keratinocytes and increased their secretion of interleukin (IL)-23, IL-12, and tumor necrosis factor (TNF)-alpha. Further, exposure of keratinocytes to IL-1 alpha, TNF-alpha, transforming growth factor-alpha, and interferon-gamma downregulated Notch1 as well as HES1, which is downstream to Notch1, but increased the Wnt5a levels. The upregulated Wnt5a in keratinocytes downregulated both Notch1 and HES1. Conclusion: Our data suggest that Wnt5a and Notch1 signaling exert counteracting influences on each other and are involved, in part, in the pathomechanism of psoriasis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN DERMATOLOGICAL ASSOC | - |
dc.title | Interaction of Wnt5a with Notch1 is Critical for the Pathogenesis of Psoriasis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Eun | - |
dc.identifier.doi | 10.5021/ad.2016.28.1.45 | - |
dc.identifier.scopusid | 2-s2.0-84957801727 | - |
dc.identifier.wosid | 000370676400007 | - |
dc.identifier.bibliographicCitation | ANNALS OF DERMATOLOGY, v.28, no.1, pp.45 - 54 | - |
dc.relation.isPartOf | ANNALS OF DERMATOLOGY | - |
dc.citation.title | ANNALS OF DERMATOLOGY | - |
dc.citation.volume | 28 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 45 | - |
dc.citation.endPage | 54 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002078168 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | SIGNALING CONTRIBUTES | - |
dc.subject.keywordPlus | KERATINOCYTE GROWTH | - |
dc.subject.keywordPlus | CELL ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | COMMITMENT | - |
dc.subject.keywordAuthor | Notch1 | - |
dc.subject.keywordAuthor | Psoriasis | - |
dc.subject.keywordAuthor | Wnt5a | - |
dc.identifier.url | https://anndermatol.org/DOIx.php?id=10.5021/ad.2016.28.1.45 | - |
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