Controlling molecular orientations of hydrogels in oil-drug@hydrogel particle delivery systems for pH-selective/sustained release and stabilization of bioactive drugs
DC Field | Value | Language |
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dc.contributor.author | Song, Ji Eun | - |
dc.contributor.author | Lim, Sora | - |
dc.contributor.author | Kim, Do-Hoon | - |
dc.contributor.author | Cho, Eun Chul | - |
dc.date.accessioned | 2022-07-15T18:32:03Z | - |
dc.date.available | 2022-07-15T18:32:03Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 0927-7757 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155186 | - |
dc.description.abstract | As potential oral and topical drug delivery applications, we fabricate oil-drug@molecularly-oriented hydrogel shells particles with regulated molecular orientation, for improved loading efficiencies, controlled and pH-specific releases, and anti-denaturation of hydrophilic drugs. The hydrogel shell is made with a natural polymer (alginate or curdlan) and Ca2+, and features oriented/crystallized structures. With a simple drop-dripping device, an optimum condition is established to encapsulate an oil-hydrophilic drug mixture with these shells and to manipulate molecular orientation/crystal structures of hydrogel shells. As a result, drug (arbutin) loading efficiencies are increased to 90% in the particles. In addition, depending on the types of physicochemical properties of hydrogel shells, not only pH-selective (in simulated gastric or intestinal fluid) but also pH-insensitive drug releases of oil-drug@hydrogel particles are possible. Moreover, due to crystals' excellent barrier properties, highly oriented hydrogels are also effective in preventing the denaturation of L-ascorbic acid, enabling long-lasting therapeutic effects of drug. This particulate system can also load a variety of functional materials in oil core of the core-shell particles and hence could expand the application to various fields. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Controlling molecular orientations of hydrogels in oil-drug@hydrogel particle delivery systems for pH-selective/sustained release and stabilization of bioactive drugs | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Eun Chul | - |
dc.identifier.doi | 10.1016/j.colsurfa.2015.11.032 | - |
dc.identifier.scopusid | 2-s2.0-84960392300 | - |
dc.identifier.wosid | 000367233200006 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v.490, pp.49 - 58 | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | - |
dc.citation.title | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | - |
dc.citation.volume | 490 | - |
dc.citation.startPage | 49 | - |
dc.citation.endPage | 58 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.subject.keywordPlus | LIQUID-CRYSTALLINE GEL | - |
dc.subject.keywordPlus | CONTROLLED PROTEIN RELEASE | - |
dc.subject.keywordPlus | BIOMEDICAL APPLICATIONS | - |
dc.subject.keywordPlus | ALGINATE GELS | - |
dc.subject.keywordPlus | ENCAPSULATION | - |
dc.subject.keywordPlus | CAPSULES | - |
dc.subject.keywordPlus | CURDLAN | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | DEVICES | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Oil-drug@hydrogel shell particles | - |
dc.subject.keywordAuthor | Molecular orientation and crystallization of hydrogel | - |
dc.subject.keywordAuthor | pH-selective and sustained drug releases | - |
dc.subject.keywordAuthor | Anti-denaturation | - |
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