Alanine aminotransferase and gamma-glutamyl transferase have different dose-response relationships with risk of mortality by age
DC Field | Value | Language |
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dc.contributor.author | Oh, Chang-Mo | - |
dc.contributor.author | Won, Young-Joo | - |
dc.contributor.author | Cho, Hyunsoon | - |
dc.contributor.author | Lee, Jong-Keun | - |
dc.contributor.author | Park, Bo young | - |
dc.contributor.author | Jun, Jae Kwan | - |
dc.contributor.author | Koh, Dong-Hee | - |
dc.contributor.author | Ki, Moran | - |
dc.contributor.author | Jung, Kyu-Won | - |
dc.contributor.author | Oh, In-Hwan | - |
dc.date.accessioned | 2022-07-15T19:01:58Z | - |
dc.date.available | 2022-07-15T19:01:58Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155254 | - |
dc.description.abstract | Background & Aims It remains unclear whether the respective dose-response relationships between serum alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) levels and risk of mortality are consistent by age. Methods We used sampled cohort data from the National Health Insurance Corporation to conduct a retrospective cohort study. A total of 313 252 participants who received medical health check-ups from 2002 to 2008 were assessed for risk of death according to serum ALT and GGT levels over an average of 6 years. The hazard ratios (HRs) for mortality were analysed with Cox proportional hazard model. Results The crude mortality rate increased linearly with increasing serum ALT and GGT levels in adults aged <60 years. However, the all-cause mortality rate showed a J-shaped relationship with increasing serum ALT levels whereas all-cause mortality rate showed a linear relationship with increasing serum GGT levels in adults aged ≥60 years. The HR of death showed U-shaped relationships with increasing serum ALT levels in adults aged ≥60 years. On the contrary, the HR of death from any cause had a linear association with increasing serum GGT levels among all age groups. Conclusions In this study, U-shaped relationship patterns were demonstrated between serum ALT levels and risk for all-cause mortality in adults aged ≥60 years while serum GGT levels showed a linear relationship with risk for all-cause death. Very low levels of serum ALT in elderly patients suggest that they are at high risk of mortality. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Alanine aminotransferase and gamma-glutamyl transferase have different dose-response relationships with risk of mortality by age | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Bo young | - |
dc.identifier.doi | 10.1111/liv.12879 | - |
dc.identifier.scopusid | 2-s2.0-84933544927 | - |
dc.identifier.wosid | 000367723500015 | - |
dc.identifier.bibliographicCitation | Liver International, v.36, no.1, pp.126 - 135 | - |
dc.relation.isPartOf | Liver International | - |
dc.citation.title | Liver International | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 126 | - |
dc.citation.endPage | 135 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | alanine aminotransferase | - |
dc.subject.keywordPlus | cholesterol | - |
dc.subject.keywordPlus | gamma glutamyltransferase | - |
dc.subject.keywordPlus | glucose | - |
dc.subject.keywordPlus | alanine aminotransferase | - |
dc.subject.keywordPlus | gamma glutamyltransferase | - |
dc.subject.keywordAuthor | Age groups | - |
dc.subject.keywordAuthor | Alanine aminotransferase | - |
dc.subject.keywordAuthor | Cause of death | - |
dc.subject.keywordAuthor | Gamma | - |
dc.subject.keywordAuthor | Glutamyl transferase | - |
dc.subject.keywordAuthor | Korea | - |
dc.subject.keywordAuthor | Mortality | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/liv.12879 | - |
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