NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal
DC Field | Value | Language |
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dc.contributor.author | Yoon, Sun Och | - |
dc.contributor.author | Kim, Eun Kyung | - |
dc.contributor.author | Lee, Mira | - |
dc.contributor.author | Jung, Woon Yong | - |
dc.contributor.author | Lee, Hyunjoo | - |
dc.contributor.author | Kang, Youngran | - |
dc.contributor.author | Jang, You-Jin | - |
dc.contributor.author | Hong, Soon Won | - |
dc.contributor.author | Choi, Seung Ho | - |
dc.contributor.author | Yang, Woo Ick | - |
dc.date.accessioned | 2022-07-15T19:02:43Z | - |
dc.date.available | 2022-07-15T19:02:43Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155262 | - |
dc.description.abstract | Occult residual disease in remnant tissues could be the cause of tumor relapse. To identify signal molecules and target cells that may be indicative of occult residual disease within a remnant microenvironment, proximal resection margin tissues of gastric cancers were used, as these correspond to the nearest remnant tissues after gastrectomy. Increased miR-146b-5p in the remnant microenvironment was determined to be a strong risk factor for tumor relapse and poor survival rate. NOVA1, a target gene of miR-146b-5p, was decreased in remnant tissues of patients with a poor prognosis. NOVA1 was enriched in stromal spindle cells such as fibroblasts within normal tissues. In non-neoplastic inflammation, such as gastritis, NOVA1 was highly enriched in T lymphocytes and stromal spindle cells, while expression of this protein was frequently decreased in those types of cells within gastric cancer tissues. Particularly, decreased NOVA1 in T cells within the gastric cancer tissues was correlated with decreased FOXP3-positive regulatory T cells and was associated with poor patient prognosis. In vitro analysis showed that the NOVA1 gene was inhibited by miR-146b-5p. In immune cells as well as stromal spindle cells, decreased NOVA1, possibly inhibited by miR-146b-5p, is a candidate biomarker predicting poor prognosis of gastric cancer patients and is also a biomarker of occult residual disease in remnant tissues after gastric cancer removal. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Woon Yong | - |
dc.identifier.doi | 10.18632/oncotarget.6542 | - |
dc.identifier.scopusid | 2-s2.0-84962208569 | - |
dc.identifier.wosid | 000369951800025 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.7, no.3, pp.2475 - 2495 | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 7 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 2475 | - |
dc.citation.endPage | 2495 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | TUMOR MICROENVIRONMENT | - |
dc.subject.keywordPlus | SURGICAL MARGINS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | HALLMARKS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | ONTOGENY | - |
dc.subject.keywordPlus | BREAST | - |
dc.subject.keywordAuthor | microenvironment | - |
dc.subject.keywordAuthor | residual disease | - |
dc.subject.keywordAuthor | hsa-microRNA-146b-5p | - |
dc.subject.keywordAuthor | NOVA1 | - |
dc.subject.keywordAuthor | stromal cells | - |
dc.identifier.url | https://www.oncotarget.com/article/6542/text/ | - |
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