HiXCorr: a portable high-speed X-Corr engine for high-resolution tandem mass spectrometryopen access
- Authors
- Kim, Hyunwoo; Jo, Hosung; Park, Heejin; Paek, Eunok
- Issue Date
- Dec-2015
- Publisher
- OXFORD UNIV PRESS
- Citation
- BIOINFORMATICS, v.31, no.24, pp.4026 - 4028
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOINFORMATICS
- Volume
- 31
- Number
- 24
- Start Page
- 4026
- End Page
- 4028
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155761
- DOI
- 10.1093/bioinformatics/btv490
- ISSN
- 1367-4803
- Abstract
- Peptide identification is an important problem in proteomics. One of the most popular scoring schemes for peptide identification is X-Corr (cross-correlation). Since calculating X-Corr is computationally intensive, a lot of efforts have been made to develop fast X-Corr engines. However, the existing X-Corr engines are not suitable for high-resolution MS/MS spectrometry because they are either slow or require a specific type of CPU. We present a portable high-speed X-Corr engine for high-resolution tandem mass spectrometry by developing a novel algorithm for calculating X-Corr. The algorithm enables X-Corr calculation 1.25-49 times faster than previous algorithms for 0.01 Da fragment tolerance. Furthermore, our engine is easily portable to any machine with different types of CPU because it is developed in C language. Hence, our X-Corr engine will expedite peptide identification by high-resolution tandem mass spectrometry.
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