Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats
DC Field | Value | Language |
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dc.contributor.author | Choi, Miyeon | - |
dc.contributor.author | Lee, Seung Hoon | - |
dc.contributor.author | Wang, Sung Eun | - |
dc.contributor.author | Ko, Seung Yeon | - |
dc.contributor.author | Song, Mihee | - |
dc.contributor.author | Choi, June-Seek | - |
dc.contributor.author | Kim, Yong-Seok | - |
dc.contributor.author | Duman, Ronald S. | - |
dc.contributor.author | Son, Hyeon | - |
dc.date.accessioned | 2022-07-15T20:03:44Z | - |
dc.date.available | 2022-07-15T20:03:44Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155766 | - |
dc.description.abstract | Ketamine produces rapid antidepressant-like effects in animal assays for depression, although the molecular mechanisms underlying these behavioral actions remain incomplete. Here, we demonstrate that ketamine rapidly stimulates histone deacetylase 5 (HDAC5) phosphorylation and nuclear export in rat hippocampal neurons through calcium/calmodulin kinase II-and protein kinase D-dependent pathways. Consequently, ketamine enhanced the transcriptional activity of myocyte enhancer factor 2 (MEF2), which leads to regulation of MEF2 target genes. Transfection of a HDAC5 phosphorylation-defective mutant (Ser259/Ser498 replaced by Ala259/Ala498, HDAC5-S/A), resulted in resistance to ketamine-induced nuclear export, suppression of ketamine-mediated MEF2 transcriptional activity, and decreased expression of MEF2 target genes. Behaviorally, viral-mediated hippocampal knockdown of HDAC5 blocked or occluded the antidepressant effects of ketamine both in unstressed and stressed animals. Taken together, our results reveal a novel role of HDAC5 in the actions of ketamine and suggest that HDAC5 could be a potential mechanism contributing to the therapeutic actions of ketamine. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Seok | - |
dc.contributor.affiliatedAuthor | Son, Hyeon | - |
dc.identifier.doi | 10.1073/pnas.1513913112 | - |
dc.identifier.scopusid | 2-s2.0-84952701116 | - |
dc.identifier.wosid | 000366916000064 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.112, no.51, pp.15755 - 15760 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 112 | - |
dc.citation.number | 51 | - |
dc.citation.startPage | 15755 | - |
dc.citation.endPage | 15760 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | MESSENGER-RNA TRANSLATION | - |
dc.subject.keywordPlus | NMDA RECEPTOR BLOCKADE | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FACTOR-2 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CAMP | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | ketamine | - |
dc.subject.keywordAuthor | HDAC | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | hippocampus | - |
dc.identifier.url | https://www.pnas.org/content/112/51/15755 | - |
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