The Wnt/beta-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
DC Field | Value | Language |
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dc.contributor.author | Kwak, Hyun Jung | - |
dc.contributor.author | Park, Dong Won | - |
dc.contributor.author | Seo, Ji-Young | - |
dc.contributor.author | Moon, Ji-Yong | - |
dc.contributor.author | Kim, Tae Hyung | - |
dc.contributor.author | Sohn, Jang Won | - |
dc.contributor.author | Shin, Dong Ho | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Park, Sung Soo | - |
dc.contributor.author | Kim, Sang-Heon | - |
dc.date.accessioned | 2022-07-15T20:05:32Z | - |
dc.date.available | 2022-07-15T20:05:32Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155781 | - |
dc.description.abstract | Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is available. The Wnt/beta-catenin signaling pathway is involved in various physiological and pathological processes, including fibrosis and smooth muscle hypertrophy. In this study, we investigated the roles of Wnt/beta-catenin signaling in airway remodeling in patients with asthma. Wnt7a mRNA expression was prominent in induced sputum from patients with asthma compared with that from healthy controls. Next, we induced a chronic asthma mouse model with airway remodeling features, including subepithelial fibrosis and airway smooth muscle hyperplasia. Higher expression of Wnt family proteins and beta-catenin was detected in the lung tissue of mice with chronic asthma compared to control mice. Blocking beta-catenin expression with a specific siRNA attenuated airway inflammation and airway remodeling. Decreased subepithelial fibrosis and collagen accumulation in the beta-catenin siRNA-treated mice was accompanied by reduced expression of transforming growth factor-beta. We further showed that suppressing beta-catenin in the chronic asthma model inhibited smooth muscle hyperplasia by downregulating the tenascin C/platelet-derived growth factor receptor pathway. Taken together, these findings demonstrate that the Wnt/beta-catenin signaling pathway is highly expressed and regulates the development of airway remodeling in chronic asthma. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | The Wnt/beta-catenin signaling pathway regulates the development of airway remodeling in patients with asthma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Dong Won | - |
dc.contributor.affiliatedAuthor | Moon, Ji-Yong | - |
dc.contributor.affiliatedAuthor | Sohn, Jang Won | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Joo | - |
dc.contributor.affiliatedAuthor | Kim, Sang-Heon | - |
dc.identifier.doi | 10.1038/emm.2015.91 | - |
dc.identifier.scopusid | 2-s2.0-85006307443 | - |
dc.identifier.wosid | 000368678600002 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.47, pp.1 - 8 | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 47 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE | - |
dc.subject.keywordPlus | WNT PATHWAY | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CANCER | - |
dc.identifier.url | https://www.nature.com/articles/emm201591 | - |
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